{"id":"W6887936744","doi":"10.17863/cam.25922","title":"A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.","year":2018,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Instituto de Salud Carlos III; Cancer Council Tasmania; Cancer Council South Australia; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; KWF Kankerbestrijding; Stockholms Läns Landsting; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; University of Cambridge; Government of Canada; Ministerio de Sanidad, Servicios Sociales e Igualdad; Universitätsklinikum Hamburg-Eppendorf; Russian Foundation for Basic Research; Institut National de la Santé et de la Recherche Médicale; Robert Bosch Stiftung; U.S. Army; University of Westminster; Cancer Council Western Australia; European Commission; European Regional Development Fund; King's College London; Cancerfonden; National Cancer Institute; University College London; Cancer Institute NSW; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; Eberhard Karls Universität Tübingen; Fondation du cancer du sein du Québec; Génome Québec; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; Swedish Cancer Foundation; Agency for Science, Technology and Research; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Deutsche Gesetzliche Unfallversicherung; University of California, Irvine; David F. and Margaret T. Grohne Family Foundation; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Genome Canada; Deutsches Krebsforschungszentrum; Vanderbilt University Medical Center; Dr. Ralph and Marian Falk Medical Research Trust; Breast Cancer Research Foundation; McGill University; World Cancer Research Fund; Helsingin ja Uudenmaan Sairaanhoitopiiri; Cancer Research UK; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Stavros Niarchos Foundation; University of Southern California; Rheinische Friedrich-Wilhelms-Universität Bonn; Oak Foundation; Avon Foundation for Women; Cancer Council NSW; Susan G. Komen for the Cure; Virginia Department of Health; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute; Vanderbilt University; Cancer Council Victoria; California Department of Public Health; U.S. Department of Health and Human Services","keywords":"Breast cancer; Gene; Genetic association; Genome-wide association study; Candidate gene; Cancer; Gene expression; Genetic variants; Case-control study; Human genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003461234,0.0001482221,0.0003760782,0.0004154466,0.0004048563,0.0005029318,0.0001823819,0.0002983615,0.001618367],"category_scores_gemma":[0.001035141,0.0001843991,0.0002682866,0.001070041,0.0001588599,0.0001170258,0.0003486506,0.0003229755,0.0003695857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001714147,"about_ca_system_score_gemma":0.0002610848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005861831,"about_ca_topic_score_gemma":0.01047785,"domain_scores_codex":[0.9997384,0.00005887895,0.00001667887,0.00009376797,0.0000453466,0.00004700211],"domain_scores_gemma":[0.9996685,0.000112762,0.00007187133,0.00005200128,0.00003939599,0.00005549916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009265267,0.0000543181,0.9585279,0.00007604172,0.0004868237,0.0005716907,0.0002474289,0.00008671336,0.02348357,0.0001207859,0.002906047,0.01251222],"study_design_scores_gemma":[0.00001901867,0.00004289841,0.9967829,0.000005887092,0.000119134,0.0003750268,0.0001074296,0.00009068957,0.0004597094,0.00005811482,0.001935632,0.000003602952],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904897,0.001515096,0.000496045,0.0003227057,0.00002206269,0.00001071973,0.006024827,0.00002395874,0.001094953],"genre_scores_gemma":[0.9916793,0.0007535981,0.0005473843,0.0001941221,0.00002187106,0.00001925103,0.005413145,0.00001507855,0.001356251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005861831,"threshold_uncertainty_score":0.01165539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009523681068160943,"score_gpt":0.245974671079279,"score_spread":0.2364509900111181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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