{"id":"W6887966177","doi":"10.17863/cam.35852","title":"Shared heritability and functional enrichment across six solid cancers.","year":2019,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research and Materiel Command; National Human Genome Research Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; National Cancer Institute; European Regional Development Fund; Instituto de Salud Carlos III; Cancer Council NSW; Cancer Council Victoria; Canadian Cancer Society Research Institute; Norris Cotton Cancer Center; U.S. Army; Hellenic Health Foundation; Freistaat Sachsen; Biomedical Research Council; Federal Agency for Scientific Organizations; Pomorski Uniwersytet Medyczny W Szczecinie; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Universidad de Oviedo; Center for Agroforestry, University of Missouri; Oulun Yliopisto; KWF Kankerbestrijding; Conseil Régional des Pays de la Loire; Vetenskapsrådet; National Medical Research Council; Norges Forskningsråd; Stockholms Läns Landsting; Association Anne de Bretagne Genetique; Helse Vest; Ligue Contre le Cancer; Associazione Italiana per la Ricerca sul Cancro; Karolinska Institutet; Vanderbilt University; Korea Health Industry Development Institute; Hungarian Scientific Research Fund; Japan Agency for Medical Research and Development; Deutsche Gesetzliche Unfallversicherung; Herlev Hospital; Swedish Cancer Foundation; Ministry of Health, Labour and Welfare; University of Southern California; Cancerfonden; American Cancer Society; Radboud Universiteit; Cancer Australia; Russian Foundation for Basic Research; Kuopion Yliopistollinen Sairaala; National Health and Medical Research Council; Deutsche Krebshilfe; Ministry of Education, Science and Technology; Academia Sinica; California Department of Public Health; National Research Foundation of Korea; National Natural Science Foundation of China; Departament d'Universitats, Recerca i Societat de la Informació; Institut National de la Santé et de la Recherche Médicale; Programme Grants for Applied Research; Ovarian Cancer Australia; Robert Bosch Stiftung; Fisher Center for Alzheimer's Research Foundation; Prostate Cancer Foundation of Australia; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; European Commission; Medizinischen Hochschule Hannover; Cancer Institute NSW; University College London; King's College London; Lon V. Smith Foundation; Health Canada; Instytut Medycyny Pracy im. prof. J. Nofera; Yayasan Sime Darby; National Institute of Dental and Craniofacial Research; University of Cambridge; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Virginia Department of Health; Government of Canada; Genome Canada; Fred C. and Katherine B. Andersen Foundation; Georgia Clinical and Translational Science Alliance; Royal Marsden NHS Foundation Trust; World Cancer Research Fund; BC Cancer Foundation; Cancer Care Ontario; Cancer Research Society; Institute of Biomedical Sciences, Academia Sinica; David F. and Margaret T. Grohne Family Foundation; Cancer Prevention and Research Institute of Texas; Cancer Council South Australia; Memorial Sloan-Kettering Cancer Center; Centre International de Recherche sur le Cancer; Kreftforeningen; Wellcome Trust; Johns Hopkins University; Sundhed og Sygdom, Det Frie Forskningsråd; Vanderbilt University Medical Center; Deutsches Krebsforschungszentrum; Peter MacCallum Foundation; Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología; Helsingin ja Uudenmaan Sairaanhoitopiiri; Kræftens Bekæmpelse; Dr. Ralph and Marian Falk Medical Research Trust; Roswell Park Cancer Institute; Compagnia di San Paolo; National Institutes of Health; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Florida Department of Health; Division of Cancer Prevention, National Cancer Institute; National Breast Cancer Foundation; European Social Fund; Medical Research Council; Mayo Foundation for Medical Education and Research; Prostate Cancer Foundation; Oak Foundation; National Center for Research Resources; Avon Foundation for Women; Stavros Niarchos Foundation; University of South Florida; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Research Foundation; Centers for Disease Control and Prevention; National Institute for Health and Care Research; National Cancer Research Institute; U.S. Department of Health and Human Services; Ministerio de Economía y Competitividad; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Ovarian Cancer Research Fund; Breast Cancer Campaign; Georgetown University; Cancer Council Tasmania; Itä-Suomen Yliopisto; Agency for Science, Technology and Research; Cancer Research Institute; Oregon Health and Science University; Cancer Research UK; Sheffield Hospitals Charity; NordForsk; U.S. Department of Defense; University of Pittsburgh; Breast Cancer Research Foundation; Junta de Castilla y León; Susan G. Komen for the Cure; Taiwan Biobank; Rutgers Cancer Institute of New Jersey; University of Texas MD Anderson Cancer Center; Princess Margaret Hospital Foundation; Moffitt Cancer Center; Minnesota Ovarian Cancer Alliance; Roy Castle Lung Cancer Foundation; California Breast Cancer Research Program; Fondation du cancer du sein du Québec","keywords":"Nucleofection; TSG101; Gestational period; Articular cartilage damage; Hyporeflexia; Liquation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000643681,0.0002639561,0.0003872339,0.001474594,0.0004518821,0.0007557663,0.0003820972,0.0005110569,0.004135209],"category_scores_gemma":[0.00270962,0.000227867,0.0005564884,0.001578496,0.0004911387,0.0002177283,0.000979494,0.0005582373,0.0003421106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429799,"about_ca_system_score_gemma":0.000347643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008718173,"about_ca_topic_score_gemma":0.008811363,"domain_scores_codex":[0.9990183,0.0002107952,0.00006961964,0.0003495898,0.0001576832,0.0001939684],"domain_scores_gemma":[0.9978021,0.0007265556,0.000717777,0.000322749,0.0001576875,0.0002731589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006604187,0.00002969887,0.9770584,0.00005812272,0.0005690587,0.0006139642,0.000163109,0.0002065925,0.01115238,0.0005924306,0.0005324762,0.008363392],"study_design_scores_gemma":[0.00001302694,0.00003241944,0.9972845,0.00001330487,0.0001950695,0.0007357537,0.000100961,0.0002131817,0.0005645797,0.0003072063,0.0005323561,0.000007680703],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944001,0.001049549,0.0009590116,0.0002851522,0.00002172722,0.000007521993,0.002163405,0.00003946922,0.001074104],"genre_scores_gemma":[0.9986142,0.0002112028,0.0002399492,0.00002967455,0.00001226106,0.000005045268,0.0005455732,0.00001188774,0.0003301143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008718173,"threshold_uncertainty_score":0.01733482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009285303641804531,"score_gpt":0.2300880160334173,"score_spread":0.2208027123916128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}