{"id":"W6887968306","doi":"10.17863/cam.94336","title":"Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.","year":2023,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Servicio Gallego de Salud; Instituto de Salud Carlos III; World Cancer Research Fund; Medical Research Council; Manchester Biomedical Research Centre; Division of Cancer Prevention, National Cancer Institute; National Institutes of Health; Hellenic Health Foundation; National University Health System; Dr. Ralph and Marian Falk Medical Research Trust; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; National Institute for Health and Care Research; University of Queensland; Centers for Disease Control and Prevention; Memorial Sloan-Kettering Cancer Center; Centre International de Recherche sur le Cancer; Kreftforeningen; Institut National Du Cancer; National Health and Medical Research Council; Ministry of Education, Science and Technology; Academia Sinica; Deutsche Krebshilfe; Cancer Institute NSW; Medizinischen Hochschule Hannover; Instituto Mexicano del Seguro Social; KWF Kankerbestrijding; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; Yayasan Sime Darby; Ministry of Public Health; Syöpäsäätiö; Vetenskapsrådet; National Medical Research Council; Norges Forskningsråd; Stockholms Läns Landsting; University of Westminster; Ligue Contre le Cancer; California Department of Public Health; National Research Foundation of Korea; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Deutsche Gesetzliche Unfallversicherung; University of Southern California; Alexander von Humboldt-Stiftung; Cancerfonden; American Cancer Society; Russian Foundation for Basic Research; Kuopion Yliopistollinen Sairaala; University of Canberra; University of Crete; Institut National de la Santé et de la Recherche Médicale; Wellcome Trust; Agence Nationale de la Recherche; Australian National University; Canadian Institutes of Health Research; European Commission; University College London; Engineering and Physical Sciences Research Council; Stavros Niarchos Foundation; Fondation de France; National Research Foundation; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; NSW Health Pathology; Freistaat Sachsen; University of Technology Sydney; Western Sydney Local Health District; National Cancer Institute; European Regional Development Fund; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Government of Canada; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; University of California; Institute of Biomedical Sciences, Academia Sinica; David F. and Margaret T. Grohne Family Foundation; Lon V. Smith Foundation; Itä-Suomen Yliopisto; Center for Agroforestry, University of Missouri; Genome Canada; Consejo Nacional de Ciencia y Tecnología; Sundhed og Sygdom, Det Frie Forskningsråd; Hunter Medical Research Institute; Deutsches Krebsforschungszentrum; Avon Foundation for Women; Oak Foundation; Breast Cancer Research Trust; Fondation du cancer du sein du Québec; Programme Grants for Applied Research; Robert Bosch Stiftung; National University of Singapore; Cancer Research UK; World Health Organization; National Research Foundation Singapore; Breast Cancer Research Foundation; University of Sydney; University of California, San Francisco; U.S. Department of Health and Human Services; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Ministry of Education, Culture, Sports, Science and Technology; Ovarian Cancer Research Fund; Taiwan Biobank; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado; Fonds Wetenschappelijk Onderzoek","keywords":"Breast cancer; Gene; Genetic association; Identification (biology); Genome-wide association study; Disease; Candidate gene; Multiple comparisons problem","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003116042,0.0005114609,0.000718473,0.001555797,0.0006689787,0.00129714,0.0005266286,0.0007224748,0.003988389],"category_scores_gemma":[0.01534335,0.0001815434,0.0008694565,0.002147047,0.0007303127,0.0004721594,0.001161097,0.001038229,0.0003532183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000305332,"about_ca_system_score_gemma":0.0003365393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004611391,"about_ca_topic_score_gemma":0.004935732,"domain_scores_codex":[0.9974994,0.001445768,0.0001228977,0.000483342,0.0002894792,0.0001590749],"domain_scores_gemma":[0.9883199,0.007728295,0.001998613,0.0009915537,0.0003820385,0.0005795519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001431816,0.00008527637,0.9510112,0.00008141754,0.001291104,0.0008068243,0.0004344342,0.0008137749,0.005160269,0.001974674,0.002441988,0.03446736],"study_design_scores_gemma":[0.0001031742,0.0002580966,0.9825106,0.00004272031,0.0005612371,0.0009768155,0.0002991601,0.004281459,0.00142227,0.006558452,0.002956801,0.00002914081],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796214,0.001803081,0.01056386,0.001402927,0.0001370872,0.00002982284,0.002189289,0.000229943,0.00402254],"genre_scores_gemma":[0.9958856,0.0002370771,0.002381496,0.0002454697,0.00008110185,0.00001976393,0.0004438743,0.00002927694,0.0006763449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004611391,"threshold_uncertainty_score":0.01647937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02843257989975511,"score_gpt":0.2769410997561073,"score_spread":0.2485085198563522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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