{"id":"W6888002375","doi":"10.17863/cam.27046","title":"Oral contraceptive use and breast cancer risk: retrospective and prospective analyses from a BRCA1 and BRCA2 mutation carrier cohort study","year":2018,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Narodowe Centrum Badań i Rozwoju; National Institutes of Health; Institut Claudius Regaud; Freistaat Sachsen; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Institut National Du Cancer; Deutsche Krebshilfe; Medizinische Universität Wien; Medical Research Council; Leids Universitair Medisch Centrum; Radboud Universitair Medisch Centrum; Fondation de France; Odense Universitetshospital; Hungarian Scientific Research Fund; Rijksuniversiteit Groningen; Ministerio de Economía y Competitividad; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Australia; Universität Wien; Lunds Universitet; Universiteit Maastricht; Institut Gustave-Roussy; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Instituto de Salud Carlos III; Radboud Universiteit; KWF Kankerbestrijding; Cancer Research UK; Government of Canada; Fondation du cancer du sein du Québec; European Regional Development Fund; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institute for Health and Care Research; Genome Canada; Maastricht Universitair Medisch Centrum; European Commission; Canadian Institutes of Health Research; Fundación Mutua Madrileña; Royal Marsden NHS Foundation Trust; Universiteit Leiden; Deutsches Krebsforschungszentrum","keywords":"Retrospective cohort study; Prospective cohort study; Breast cancer; BRCA mutation; Cohort study; Proportional hazards model; Mutation; Relative risk","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113968,0.000150215,0.0002458948,0.00006681417,0.0002468676,0.0000339089,0.00007189,0.00009712717,0.00002058848],"category_scores_gemma":[0.00004673843,0.0001715659,0.00003594384,0.0001363543,0.0006470749,0.00004273235,0.0001313823,0.00008755015,6.934827e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001041437,"about_ca_system_score_gemma":0.00008543124,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02000953,"about_ca_topic_score_gemma":0.007504909,"domain_scores_codex":[0.9989966,0.0001013418,0.00009655827,0.0005284685,0.0001379324,0.0001390884],"domain_scores_gemma":[0.9991262,0.00002534652,0.0001606435,0.0002002905,0.0004031829,0.0000843656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003126185,0.00004800419,0.9813786,0.000003550276,0.0008048906,0.000006158969,0.002437667,0.000004794357,0.01345525,0.00002049589,0.0004445103,0.001083509],"study_design_scores_gemma":[0.001738673,0.0003557385,0.9861376,0.00001058453,0.000450626,0.00001274811,0.006550428,0.0001844582,0.004236994,0.00003047645,0.0001076363,0.0001840102],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965108,0.0004184006,0.001115982,0.00007766939,0.00005919318,0.0004957357,0.001195542,0.00001014574,0.0001165519],"genre_scores_gemma":[0.9986029,0.0003340493,0.0005676534,0.00002744175,0.00008349137,0.000003427024,0.00003311414,0.0000131295,0.0003348416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01250463,"threshold_uncertainty_score":0.9865163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245517813364397,"score_gpt":0.2664197739441542,"score_spread":0.2539645958105102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}