{"id":"W6888996816","doi":"10.24433/co.5276438.v1","title":"LINE1 elements are hijacking by genetic and epigenetic variation drives metastatic prostate cancer","year":2025,"lang":"en","type":"other","venue":"Code Ocean","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Chromatin; Epigenetics; Prostate cancer; Transposable element; Genome; Chromoplexy; Epigenomics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001809528,0.0005799719,0.0006149615,0.0004586129,0.0001001025,0.0001334601,0.0002903149,0.0001645681,0.001161365],"category_scores_gemma":[0.00008748306,0.0005982895,0.0000661297,0.0003509698,0.0001004367,0.00004887937,0.0001521764,0.000236221,0.0002460487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927566,"about_ca_system_score_gemma":0.0002220838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003844689,"about_ca_topic_score_gemma":0.0008719729,"domain_scores_codex":[0.9974655,0.0002103723,0.0005156332,0.0008693111,0.0004197409,0.0005194603],"domain_scores_gemma":[0.9983381,0.00004872139,0.0008532316,0.0005103834,0.0001050258,0.0001445089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003722553,0.0001473407,0.05045893,0.00134412,0.001188163,0.00002908892,0.0008065961,0.0002062927,0.001401598,0.00004435735,0.9337148,0.01062149],"study_design_scores_gemma":[0.004060401,0.0001708082,0.03514391,0.004674626,0.002656289,0.000005097382,0.0002293906,0.00406745,0.0006718487,0.001066665,0.9450591,0.002194457],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.08749388,0.5029983,0.01751507,0.001539659,0.007479898,0.02914673,0.1310912,0.006932784,0.2158025],"genre_scores_gemma":[0.03150264,0.008335735,0.01170265,0.000336651,0.0003925471,0.000193194,0.001250118,0.002873912,0.9434125],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.7276101,"threshold_uncertainty_score":0.9997517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126318617479228,"score_gpt":0.2791467896121734,"score_spread":0.2665149278642506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}