{"id":"W6889159773","doi":"10.25418/crick.19803214.v1","title":"Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment","year":2022,"lang":"en","type":"article","venue":"Open MIND","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Janssen Research and Development; U.S. National Library of Medicine; National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; Faculty of Medicine and Health, University of Sydney; Vanderbilt University; Royal Society of Tropical Medicine and Hygiene; Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa; Statens Serum Institut; Medical Research Council; Leibniz-Gemeinschaft; Morsani College of Medicine; Imperial College London; School of Medicine, Emory University; National Institute for Health and Care Research; Centers for Disease Control and Prevention; National Institutes of Health; Universitätsklinikum Heidelberg; National Center for Genetic Engineering and Biotechnology; Vetenskapsrådet; National Health Laboratory Service; Assistance publique-Hôpitaux de Paris; Science for Life Laboratory; Russian Academy of Sciences; China Medical University Hospital; Otsuka Pharmaceutical; Fogarty International Center; Universität Zürich; Uniwersytet Warszawski; Suez University; Instituto de Investigación Sanitaria del Principado de Asturias; Universidade Nova de Lisboa; Public Health Agency of Canada; Universitat de Barcelona; Centre National de la Recherche Scientifique; Inyuvesi Yakwazulu-Natali; National Science and Technology Development Agency; Universitätsklinikum Hamburg-Eppendorf; Universiteit Stellenbosch; Narodowym Centrum Nauki; University of Colombo; Universiteit Antwerpen; Linköpings Universitet; Fudan University; Ege Üniversitesi; Folkhälsomyndigheten; National Institute for Research in Tuberculosis; London School of Hygiene and Tropical Medicine; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Bristol; European Society of Clinical Microbiology and Infectious Diseases; National Taiwan University; Institut National de la Santé et de la Recherche Médicale; Indian Council of Medical Research; Lomonosov Moscow State University; National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention; Fundação para a Ciência e a Tecnologia; Radboud Universiteit; Radboud Universitair Medisch Centrum; University of Pretoria; Capital Medical University; South African Medical Research Council; Istituto Superiore di Sanità; Consejo Superior de Investigaciones Científicas; National Institute of Diabetes and Digestive and Kidney Diseases; Royal Society; National Institute of Mental Health; Case Western Reserve University; University of Sydney; Innosuisse - Schweizerische Agentur für Innovationsförderung; Australian Government; China Medical University; National Science Foundation; Universidade Federal do Espírito Santo; Chinese People’s Liberation Army; University of Cape Town; NIHR Cambridge Biomedical Research Centre; Massachusetts General Hospital; Emerging Pathogens Institute, University of Florida; Kungliga Tekniska Högskolan; Sorbonne Université; UK Research and Innovation; Universidad Pontificia Bolivariana; Bundesministerium für Bildung und Forschung; Francis Crick Institute; World Health Organization; Johns Hopkins University; Wellcome Trust; Cancer Research UK; Otsuka Pharmaceutical Development and Commercialization; Ministerie van Buitenlandse Zaken; Vanderbilt University Medical Center; Department of Foreign Affairs and Trade, Australian Government; Public Health Agency; NSW Health Pathology; Instituut voor Tropische Geneeskunde; National Taiwan University Hospital; Deutsches Zentrum für Infektionsforschung; Emory University; University of Bern; California Department of Public Health; University of South Florida; University of California, San Diego; Bill and Melinda Gates Foundation","keywords":"Disease; MEDLINE; Resistance (ecology); Component (thermodynamics)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08194357,0.001059933,0.002817611,0.006230609,0.002140001,0.0120933,0.006437925,0.007677197,0.01159462],"category_scores_gemma":[0.2207451,0.0008659006,0.00182955,0.004632059,0.006531837,0.01635943,0.005443474,0.01143173,0.006886582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00467671,"about_ca_system_score_gemma":0.01651415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01201017,"about_ca_topic_score_gemma":0.02094619,"domain_scores_codex":[0.9456708,0.02975324,0.01008425,0.002341965,0.01093004,0.001219645],"domain_scores_gemma":[0.7414203,0.1212185,0.01728946,0.01557671,0.0953445,0.009150499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002267058,0.0002998406,0.0109084,0.004116729,0.0001149821,0.0002770695,0.002099824,0.0003981172,0.001257314,0.02138952,0.26102,0.6978915],"study_design_scores_gemma":[0.0001258181,0.0003834403,0.01596531,0.01561672,0.0003144432,0.002591781,0.007064235,0.001467273,0.00182245,0.06121976,0.8930619,0.0003668281],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.006021695,0.1196085,0.04305879,0.7454696,0.04654117,0.0004828949,0.001302428,0.000747998,0.03676687],"genre_scores_gemma":[0.08712759,0.2611152,0.295599,0.275634,0.04918478,0.001081193,0.002323743,0.001212034,0.02672249],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.08194357,"threshold_uncertainty_score":0.4333642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2676451659186945,"score_gpt":0.4018853925433655,"score_spread":0.134240226624671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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