{"id":"W6891613268","doi":"10.48448/agh8-r777","title":"Investigating regional lipid expression profiles in post-mortem Alzheimer's disease brain tissue using MALDI-IMS","year":2021,"lang":"en","type":"other","venue":"Underline Science Inc.","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Lipidomics; Neuropathology; Lipid metabolism; Neuroprotection; Dementia; Entorhinal cortex; White matter; Mass spectrometry imaging; Laser capture microdissection; Human brain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001662391,0.0008525695,0.0007428064,0.002148221,0.000470239,0.0004050746,0.001589958,0.0003782836,0.001849731],"category_scores_gemma":[0.001559945,0.0008270105,0.0001126285,0.003330912,0.002872142,0.0006326438,0.0009821031,0.0008195593,0.0003473071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005035771,"about_ca_system_score_gemma":0.005432912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001280951,"about_ca_topic_score_gemma":0.0009162803,"domain_scores_codex":[0.9927644,0.000421172,0.0008685076,0.002203507,0.002406832,0.001335654],"domain_scores_gemma":[0.9961003,0.0001997105,0.0009527368,0.001342133,0.0003621402,0.001042965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004182368,0.0005732235,0.006960415,0.0003492706,0.00008107409,0.0005559918,0.0007832742,0.001853937,0.8465399,0.001663941,0.1346779,0.005919312],"study_design_scores_gemma":[0.007864538,0.000701403,0.02073328,0.06677944,0.001146016,0.0007503885,0.007122675,0.316482,0.09614368,0.004261119,0.4619651,0.01605045],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5233791,0.1080584,0.004897574,0.02843339,0.01666174,0.02991841,0.008442588,0.01106623,0.2691424],"genre_scores_gemma":[0.2467013,0.0002110549,0.5687146,0.01051328,0.01348535,0.0006541286,0.008669285,0.01032895,0.1407221],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7503962,"threshold_uncertainty_score":0.9998415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07299407504059101,"score_gpt":0.3580565820659367,"score_spread":0.2850625070253457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}