{"id":"W6891642647","doi":"10.48448/g04k-2v66","title":"A positive allosteric modulator of M1 Acetylcholine receptors improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice","year":2021,"lang":"en","type":"other","venue":"Underline Science Inc.","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Allosteric modulator; Morris water navigation task; Acetylcholine; Hippocampal formation; Agonist; Allosteric regulation; Hippocampus; Acetylcholine receptor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001229709,0.0007390945,0.001215438,0.002149026,0.0001278332,0.00009714231,0.00071788,0.0005570715,0.0004102698],"category_scores_gemma":[0.0009985975,0.0007330038,0.0001014447,0.003160663,0.003751193,0.0002713325,0.0008355221,0.000662505,0.0001296346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025956,"about_ca_system_score_gemma":0.0009634956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007137437,"about_ca_topic_score_gemma":0.00235391,"domain_scores_codex":[0.9950097,0.0003436538,0.0008141586,0.001919478,0.0008872636,0.001025756],"domain_scores_gemma":[0.9973032,0.0003185347,0.0009265704,0.0005755831,0.0005802176,0.0002958953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003747616,0.001597735,0.00409378,0.0006823798,0.0002819568,0.0005560953,0.005106684,0.00004142934,0.9529487,0.000805604,0.002645577,0.03086529],"study_design_scores_gemma":[0.06478475,0.01375857,0.1311159,0.05421136,0.004828648,0.008595381,0.1070227,0.06669223,0.4801261,0.003234904,0.03408101,0.03154844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9278643,0.007819553,0.0006268842,0.000179309,0.001114307,0.002707534,0.001948525,0.0002728284,0.05746678],"genre_scores_gemma":[0.9566565,0.0003430489,0.01215561,0.0003654973,0.0002540027,0.00008612258,0.0005952248,0.0008809536,0.02866303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4728227,"threshold_uncertainty_score":0.9995121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864775212913665,"score_gpt":0.2882546980454933,"score_spread":0.2696069459163566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}