{"id":"W6892508065","doi":"10.5281/zenodo.10818213","title":"Antibody Characterization Report for Casein kinase II subunit alpha (CSNK2A1)","year":2024,"lang":"en","type":"article","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Immunoprecipitation; Antibody; Alpha (finance); Casein kinase 2; Protein subunit; Kinase; Autism; Cell culture; G alpha subunit","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":{"n_in":0,"stratum":"aff_core","weight":5595.2375,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"low","reason":"Antibody characterization report benchmarking commercial antibodies against CSNK2A1 with knockout-controlled protocols; the closest rubric anchor (Western blot protocol reproducibility) puts reagent-level validation OUT, yet such standardized characterization campaigns are explicitly reagent-reproducibility infrastructure, so this sits on the boundary."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"The study evaluates antibody performance in laboratory assays rather than research practice itself."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"medium","reason":"Lab reagent antibody characterization and assay performance; polysemy of validation, not study of research practice."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001559151,0.002422739,0.001342017,0.003136137,0.001605136,0.001153868,0.0017503,0.001232949,0.03582894],"category_scores_gemma":[0.002847887,0.001410577,0.001178043,0.001893618,0.0004443884,0.001049926,0.0009405969,0.002685661,0.0486748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006976145,"about_ca_system_score_gemma":0.001349628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537003,"about_ca_topic_score_gemma":0.002310885,"domain_scores_codex":[0.9983327,0.0002118062,0.0002674947,0.0004593236,0.0004720957,0.0002565873],"domain_scores_gemma":[0.9975252,0.0003862778,0.0001766506,0.0005156137,0.001084721,0.0003114513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000299021,0.0001435624,0.0004628533,0.0008081613,0.00008190331,0.0003039947,0.0001287008,0.0001959024,0.9641307,0.0009893761,0.01721334,0.01524244],"study_design_scores_gemma":[0.0001884358,0.0004104787,0.005393544,0.0002219628,0.0002368323,0.003345244,0.000125872,0.001802372,0.476546,0.0007761583,0.5108517,0.0001013633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1289814,0.02709192,0.6602188,0.003151402,0.005086386,0.006675146,0.1115265,0.006696339,0.05057209],"genre_scores_gemma":[0.1132691,0.02305505,0.3214417,0.001454328,0.00100299,0.007999226,0.4386786,0.003477339,0.08962172],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03582894,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212870163112533,"score_gpt":0.2819313440484083,"score_spread":0.2598026424172829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}