{"id":"W6894228788","doi":"10.5282/edoc.33807","title":"Combining connectivity, related pathologies, and genetic factors to explain tau accumulation in Alzheimer’s disease","year":2024,"lang":"en","type":"dissertation","venue":"","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; University of California, San Diego; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Knut och Alice Wallenbergs Stiftelse; Servier; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Skånes universitetssjukhus; U.S. Department of Defense; Eli Lilly and Company; China Scholarship Council; Vetenskapsrådet; Eisai; Lunds Universitet; Northern California Institute for Research and Education; Australian Government; F. Hoffmann-La Roche; University of Southern California; Pfizer; BioClinica; Biogen; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Cure Alzheimer's Fund; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Disease; Identification (biology); Population; Mutation; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005282981,0.0007514313,0.0003952866,0.0006861626,0.0003276933,0.000909318,0.0003647924,0.0005767915,0.002428876],"category_scores_gemma":[0.001101468,0.0001658866,0.0005835426,0.000431785,0.0003911438,0.001048772,0.0004563177,0.0007930388,0.0002480661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003981687,"about_ca_system_score_gemma":0.0004064635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264808,"about_ca_topic_score_gemma":0.002236325,"domain_scores_codex":[0.9999264,0.00001887325,0.000005132511,0.00002011156,0.00001530972,0.0000141648],"domain_scores_gemma":[0.9997389,0.0001029853,0.00006494018,0.00002773068,0.00003390069,0.00003160353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003437184,0.00171056,0.3660251,0.001376078,0.002967912,0.005698359,0.002283569,0.01701308,0.1951754,0.05279741,0.01002779,0.3414876],"study_design_scores_gemma":[0.0002633954,0.001140303,0.7370969,0.0005390933,0.002454179,0.005054979,0.001326431,0.02457942,0.01460619,0.2043428,0.008494048,0.0001022368],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9564013,0.01025642,0.01087966,0.004450967,0.000171387,0.00009727953,0.0006344033,0.0001084208,0.01700018],"genre_scores_gemma":[0.9832322,0.006596246,0.006608972,0.0002482822,0.0001972526,0.000047273,0.0003270954,0.00003124933,0.002711416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002428876,"threshold_uncertainty_score":0.008125424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07305010501990862,"score_gpt":0.3786503092905375,"score_spread":0.3056002042706289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}