{"id":"W6901730064","doi":"10.60692/126q8-qjk05","title":"Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity","year":2017,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Ivermectin; Onchocerca volvulus; Onchocerciasis; Quantitative trait locus; Genotyping; Genetic diversity; Genetic variation; Gene; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173584,0.0001719582,0.000168899,0.0005023803,0.000155384,0.0002597767,0.0001024933,0.0001488,0.0006865721],"category_scores_gemma":[0.0003500833,0.00008833653,0.0001936503,0.000497659,0.0001807847,0.00009212706,0.0001832455,0.0002248276,0.00008073711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193043,"about_ca_system_score_gemma":0.000104807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002459001,"about_ca_topic_score_gemma":0.00484807,"domain_scores_codex":[0.9998628,0.00001661886,0.000006917775,0.00006569044,0.00002455642,0.00002339312],"domain_scores_gemma":[0.9998069,0.00005773572,0.00008146399,0.00001217468,0.00001650163,0.00002521363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005255496,0.00006425762,0.3283518,0.0001995856,0.0004220181,0.0002345003,0.0002446822,0.0008966532,0.6467779,0.0001990541,0.0005480013,0.021536],"study_design_scores_gemma":[0.000005105051,0.00005257119,0.9960452,0.000004573643,0.00004241767,0.00008775751,0.00005271186,0.0004889675,0.00272369,0.00003647537,0.0004560437,0.000004391107],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983732,0.0003005435,0.0002633746,0.00002007767,0.000003264292,0.00000359004,0.0008292035,0.00002083158,0.0001860404],"genre_scores_gemma":[0.9984378,0.0001645486,0.0002374646,0.00003241808,0.000002293963,0.000006118149,0.0008845688,0.000007264997,0.0002276026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002459001,"threshold_uncertainty_score":0.004889369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01896739626478457,"score_gpt":0.2700892714720547,"score_spread":0.2511218752072702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}