{"id":"W6902060190","doi":"10.6084/m9.figshare.26704068","title":"Additional file 8 of Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Purine; Purine metabolism; Glioma; Enzyme; Metabolic pathway; Glioblastoma; Purine analogue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00001501269,0.0001283432,0.0001151152,0.00005680265,0.00001808393,0.00001980918,0.0001346376,0.0001136018,0.7866281],"category_scores_gemma":[0.0007442713,0.0001060238,0.0001008946,0.0001805116,0.00001946727,0.000002933395,0.0001061291,0.0000763869,0.0002543427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002656194,"about_ca_system_score_gemma":0.000125265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002695917,"about_ca_topic_score_gemma":0.0000572637,"domain_scores_codex":[0.9991425,0.00002471363,0.0001573903,0.0003221577,0.0001451664,0.0002081143],"domain_scores_gemma":[0.999537,0.00009465464,0.00002620077,0.0002177007,0.00005679113,0.00006767098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003435051,0.0001342634,2.972566e-7,0.0001472841,0.00002378608,0.0001050906,0.000008452775,1.624997e-7,0.2026194,0.000003068701,0.7963437,0.0005800606],"study_design_scores_gemma":[0.0001617514,0.0001139638,0.0000768673,0.0008323628,0.000001878664,0.000007167744,0.000002219532,0.00001956966,0.3279113,0.00002968605,0.6707597,0.00008345031],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.005518259,0.001997219,3.159687e-7,0.00008568105,0.000007649207,0.0001816372,0.9903544,0.00001462416,0.001840177],"genre_scores_gemma":[0.0508238,0.00001152416,0.0002606451,0.00001869085,0.0001195482,0.0008474058,0.9435799,0.00002194498,0.004316526],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.7863738,"threshold_uncertainty_score":0.4323525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744470803312386,"score_gpt":0.2644043062296646,"score_spread":0.2469595981965407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}