{"id":"W6902439277","doi":"10.6084/m9.figshare.c.5358079.v1","title":"Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease","year":2021,"lang":"en","type":"other","venue":"Figshare","topic":"Geological and Geochemical Analysis","field":"Earth and Planetary Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Neurodegeneration; Atrophy; White matter; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Brain size; Cerebrospinal fluid; Magnetic resonance imaging; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003972152,0.0004290217,0.0002964866,0.0006708752,0.0002111674,0.0004693162,0.0002248582,0.0003609964,0.001112342],"category_scores_gemma":[0.001192239,0.0001694956,0.0002183665,0.0004841958,0.0002002415,0.0002491976,0.0001724467,0.0003333671,0.0002204344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002621991,"about_ca_system_score_gemma":0.0001836621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0026663,"about_ca_topic_score_gemma":0.001954242,"domain_scores_codex":[0.9998649,0.00002971881,0.00001302031,0.00004910402,0.00002717412,0.0000160972],"domain_scores_gemma":[0.9991785,0.0001511766,0.0004681679,0.00004266516,0.00007693048,0.00008248084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001064632,0.00009607209,0.9884518,0.00003918171,0.0001224148,0.0001432787,0.00004746335,0.0001598703,0.004913729,0.00002748724,0.0001334485,0.004800505],"study_design_scores_gemma":[0.00001008005,0.0001848154,0.9977514,0.000004448947,0.00003530717,0.0003308625,0.00002154527,0.0004536279,0.0009638421,0.00007905962,0.0001620517,0.000002991115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978095,0.0009517082,0.0002456525,0.00005531418,0.000006542442,0.000008968796,0.0004762427,0.00001494299,0.000431245],"genre_scores_gemma":[0.9988179,0.0002298399,0.0003870474,0.00003104973,0.00001479087,0.000009648175,0.000274098,0.000001989079,0.0002336262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0026663,"threshold_uncertainty_score":0.005301535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02870647889436706,"score_gpt":0.2200112400328216,"score_spread":0.1913047611384545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}