{"id":"W6902829384","doi":"10.7916/d8xk8fmr","title":"Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk","year":2013,"lang":"en","type":"article","venue":"Columbia Academic Commons (Columbia University)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norway Grants; Medical Research Council; lékařská fakulta Univerzity Karlovy; National Institutes of Health; Institut Català de la Salut; Ministero dello Sviluppo Economico; Istituto Oncologico Veneto; Clalit Health Services; Sahlgrenska Universitetssjukhuset; National Cancer Institute; Landspítali Háskólasjúkrahús; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Israel Cancer Association; Hungarian Scientific Research Fund; National Health and Medical Research Council; Ministério da Ciência, Tecnologia e Inovação; Jewish General Hospital; Andrew Sabin Family Foundation; Lunds Universitet; University of California, San Francisco; Ministero della Salute; Canadian Institutes of Health Research; University of California, Los Angeles; Cancerfonden; Cancer Australia; European Regional Development Fund; National Breast Cancer Foundation; Russian Foundation for Basic Research; Cancer Research UK; Breast Cancer Research Foundation; Generalitat de Catalunya; University of Chicago; McGill University; Univerzita Karlova v Praze; Canadian Breast Cancer Research Alliance; Uppsala Universitet; Memorial Sloan-Kettering Cancer Center; Instituto de Salud Carlos III; Ohio State University; Mayo Clinic","keywords":"Ovarian cancer; Breast cancer; Locus (genetics); Genome-wide association study; Population; Case-control study; Etiology; Lifetime risk","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001309276,0.0005920886,0.0006276679,0.001061726,0.0004772928,0.0006045474,0.0003960434,0.0007282992,0.002782301],"category_scores_gemma":[0.002921902,0.0003199214,0.00108536,0.00131715,0.0003709401,0.0002519925,0.0004461152,0.0006721219,0.0002688048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001827848,"about_ca_system_score_gemma":0.0002603626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003516225,"about_ca_topic_score_gemma":0.003986405,"domain_scores_codex":[0.9993443,0.000186117,0.00005670145,0.0002433494,0.0000784674,0.00009100676],"domain_scores_gemma":[0.998647,0.0005462464,0.0004179582,0.0001535848,0.00007326798,0.0001619096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001406972,0.00007813053,0.9775534,0.00006103136,0.001413432,0.001582469,0.0002391577,0.0002670246,0.01039085,0.0001585599,0.0006411002,0.006207926],"study_design_scores_gemma":[0.00009872518,0.0001216619,0.9959958,0.00001545562,0.0007122959,0.0009129338,0.00008232985,0.0005779339,0.0006185313,0.0001951201,0.0006577835,0.00001158392],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981382,0.0008371386,0.0003103871,0.00008424553,0.00001930625,0.000008474572,0.0002945681,0.00001839029,0.0002893449],"genre_scores_gemma":[0.9989028,0.0002480285,0.0002703908,0.0000492709,0.00002455412,0.00001078827,0.0002738587,0.00001064523,0.0002095321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003516225,"threshold_uncertainty_score":0.009307742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008641334792965333,"score_gpt":0.2151973579093174,"score_spread":0.206556023116352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}