{"id":"W6903106558","doi":"10.1073/pnas.1012596108/-/dcsupplemental","title":"Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase","year":2011,"lang":"en","type":"article","venue":"National Research Council Canada (Government of Canada)","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Argonne National Laboratory; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; Canadian Light Source; Eli Lilly and Company; U.S. Department of Energy","keywords":"Escherichia coli; Substrate (aquarium); Covalent bond; Substrate specificity; Enzyme; Dihydroxyacetone phosphate; Escherichia coli Proteins; Kinase; Dihydroxyacetone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003358685,0.0001393912,0.0001369792,0.00001994463,0.0002267081,0.00001463992,0.0001731648,0.00007668181,0.0001065877],"category_scores_gemma":[0.004396931,0.0001399225,0.00001809412,0.0001332843,0.00009104151,0.000009536799,0.00009447354,0.0001546831,9.812371e-8],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.008425637,"about_ca_system_score_gemma":0.04442718,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.563895,"about_ca_topic_score_gemma":0.9658616,"domain_scores_codex":[0.970261,0.0000824133,0.0002163805,0.0002926669,0.02882939,0.0003181725],"domain_scores_gemma":[0.993468,0.00003784991,0.0000884124,0.0001455339,0.006049141,0.0002110499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002114066,0.00001517131,0.00005988369,0.00003671833,0.00004102042,0.000005978434,0.00003204553,0.00001138631,0.7919896,0.001809952,0.205677,0.0001098176],"study_design_scores_gemma":[0.0004931354,0.0001361943,0.001204189,0.00001404082,0.00001090858,0.000003394345,0.0001869966,0.0002096158,0.5999611,0.0001805993,0.397411,0.0001888573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658619,0.0009779234,0.00006939747,0.0002368406,0.0003196577,0.0002181731,0.0004899355,0.000002667934,0.03182346],"genre_scores_gemma":[0.9986682,0.0001188232,0.0001350766,0.0002043496,0.0000728945,0.00001408274,0.0000111422,0.00001483687,0.0007605987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4019666,"threshold_uncertainty_score":0.9953808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04692115584216029,"score_gpt":0.2388873523679165,"score_spread":0.1919661965257562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}