{"id":"W6903106558","doi":"10.1073/pnas.1012596108/-/dcsupplemental","title":"Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase","year":2011,"lang":"en","type":"article","venue":"National Research Council Canada (Government of Canada)","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Argonne National Laboratory; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; Canadian Light Source; Eli Lilly and Company; U.S. Department of Energy","keywords":"Escherichia coli; Substrate (aquarium); Covalent bond; Substrate specificity; Enzyme; Dihydroxyacetone phosphate; Escherichia coli Proteins; Kinase; Dihydroxyacetone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002637626,0.0004515264,0.0003391925,0.0001029921,0.0005647285,0.0007472503,0.0006148205,0.0005193096,0.001942543],"category_scores_gemma":[0.0003151895,0.0002812154,0.000221676,0.0001472733,0.0005277777,0.0005604901,0.0004177757,0.0009702191,0.0004464628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001134131,"about_ca_system_score_gemma":0.0007229786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003491506,"about_ca_topic_score_gemma":0.004280974,"domain_scores_codex":[0.9999032,0.00001016907,0.000006179767,0.00001574887,0.00003323771,0.00003136744],"domain_scores_gemma":[0.9999026,0.00003125452,0.00002049356,0.0000125714,0.0000108699,0.00002221705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001253574,0.0006605003,0.006317104,0.0006387455,0.00009224785,0.003335961,0.000495977,0.03219373,0.8528466,0.06560482,0.001645524,0.03491528],"study_design_scores_gemma":[0.00009750682,0.0005525402,0.006368924,0.00003957579,0.00007389501,0.001275926,0.0006013194,0.05926529,0.9102516,0.008715143,0.0126926,0.00006570716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788024,0.001847735,0.01120116,0.001023658,0.0001064425,0.00004109975,0.0001096703,0.0002445157,0.00662335],"genre_scores_gemma":[0.996097,0.0007697123,0.001305061,0.0001020408,0.000008083545,0.00000607987,0.00007263925,0.000008890433,0.001630455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003491506,"threshold_uncertainty_score":0.008228719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04692115584216029,"score_gpt":0.2388873523679165,"score_spread":0.1919661965257562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}