{"id":"W6903113640","doi":"10.1021/bi101808h.s001","title":"Mechanistic Evaluation of <i>MelA</i> α-Galactosidase from <i>Citrobacter freundii</i>: A Family 4 Glycosyl Hydrolase in Which Oxidation Is Rate-Limiting","year":2016,"lang":"en","type":"article","venue":"Figshare","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Hydrolase; Kinetic isotope effect; Glycosyl; Hydrolysis; Deuterium; Glycoside hydrolase; Leaving group; Enzyme; Substrate (aquarium); Glycal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006344586,0.0006785945,0.0003705035,0.0001155772,0.0002431503,0.0006216262,0.0007699358,0.0005055809,0.001489936],"category_scores_gemma":[0.0003941003,0.0001712527,0.0004222468,0.0001501141,0.0003879771,0.0008353569,0.0003686371,0.001522616,0.0004572475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008603751,"about_ca_system_score_gemma":0.0005936861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001651292,"about_ca_topic_score_gemma":0.00185573,"domain_scores_codex":[0.9997969,0.00003129986,0.000008872988,0.00003527683,0.00004655818,0.00008109753],"domain_scores_gemma":[0.9998788,0.00002061376,0.00001961097,0.00001255933,0.00003544298,0.00003302555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007873898,0.0007190115,0.001228599,0.0007043189,0.00005124725,0.0004428156,0.0001489405,0.005293295,0.9712639,0.006724075,0.001152583,0.01148381],"study_design_scores_gemma":[0.0000415098,0.00123768,0.001123419,0.00004229591,0.00003245282,0.0002197895,0.0001602726,0.01011472,0.9677534,0.001173091,0.01807441,0.00002710283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456406,0.0068897,0.02451461,0.00147891,0.0002344875,0.0003767098,0.001102881,0.0002216368,0.01954045],"genre_scores_gemma":[0.9881051,0.002617394,0.005676239,0.0001685743,0.00001371528,0.00008705852,0.0006343744,0.00003004487,0.002667474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651292,"threshold_uncertainty_score":0.006242514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415744529624571,"score_gpt":0.2512519465966381,"score_spread":0.2270945013003924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}