{"id":"W6903398019","doi":"10.1021/ml100029k.s001","title":"The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor","year":2016,"lang":"en","type":"article","venue":"Figshare","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Potency; In vivo; Drug discovery; Potassium channel; Drug development; Identification (biology); In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000235592,0.0005508011,0.0004359764,0.0006801967,0.0001993986,0.000466522,0.0004602282,0.0006174292,0.001646387],"category_scores_gemma":[0.0001438723,0.0002180436,0.0004228788,0.0002910097,0.0003936891,0.0003644035,0.0004396285,0.001156794,0.0006304291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006188181,"about_ca_system_score_gemma":0.0004062767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002716201,"about_ca_topic_score_gemma":0.0008233783,"domain_scores_codex":[0.9998857,0.00001728947,0.000006538453,0.00001963838,0.00004390294,0.00002697718],"domain_scores_gemma":[0.9999357,0.000007389644,0.00001575521,0.000005214827,0.00001312927,0.00002281182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005888831,0.0003004078,0.0006368443,0.001076156,0.00008438317,0.00120726,0.0001313503,0.002030388,0.8485107,0.006434753,0.003225699,0.1357732],"study_design_scores_gemma":[0.0008003033,0.008835023,0.003789477,0.000170874,0.0001829113,0.00425597,0.00006411991,0.003195046,0.830898,0.001418916,0.1462857,0.0001036032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7685454,0.1293251,0.0532333,0.004854751,0.001130262,0.001043293,0.002201835,0.0008093801,0.03885666],"genre_scores_gemma":[0.9252419,0.03653833,0.01755929,0.0009371246,0.000182766,0.0002193648,0.001819076,0.00004623543,0.01745585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646387,"threshold_uncertainty_score":0.005507767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353515430981153,"score_gpt":0.2472834545971274,"score_spread":0.2337483002873159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}