{"id":"W6903621888","doi":"10.1158/1538-7445.am2025-6782","title":"Abstract 6782: ACADS as a novel target of selinexor activity in diffuse large B cell lymphoma","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Greenfield Research (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Mitochondrion; Lymphoma; Glycolysis; Cell; Stable isotope labeling by amino acids in cell culture; Cell culture; Extracellular; Diffuse large B-cell lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003444467,0.00008614036,0.0001189848,0.0001218023,0.00005366908,0.00001292623,0.000183961,0.0001790488,0.0000747757],"category_scores_gemma":[0.00007898931,0.00008021642,0.00004972114,0.0002796343,0.00006874349,0.000004783142,0.000134827,0.0001895082,0.000007609419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005732854,"about_ca_system_score_gemma":0.0003372199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005372767,"about_ca_topic_score_gemma":0.0002295002,"domain_scores_codex":[0.9990752,0.00004408913,0.0001248644,0.0002787477,0.0001814592,0.0002956532],"domain_scores_gemma":[0.9994959,0.00002139877,0.00003196206,0.0002726815,0.0001309701,0.00004713409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000435892,0.0005790956,0.002227415,0.0000912484,0.00001908789,0.000001988689,0.00004042682,0.000009173131,0.9905847,0.00009839797,0.002336899,0.003575623],"study_design_scores_gemma":[0.003108528,0.00009228533,0.04138294,0.00003107698,0.000003541899,6.097771e-7,0.00007048069,0.00004067545,0.8860891,0.0001316517,0.06896352,0.00008552489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936154,0.0005925253,0.0001622082,0.0002195723,0.0001351897,0.0001650826,0.00005432542,0.000004689265,0.005050961],"genre_scores_gemma":[0.9973789,0.0003009583,0.00007549873,0.0001085783,0.0001175729,0.00003233782,0.00001925609,0.00001317387,0.001953714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1044956,"threshold_uncertainty_score":0.3271131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02200956890494683,"score_gpt":0.3604071571814801,"score_spread":0.3383975882765333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}