{"id":"W6906635383","doi":"10.17863/cam.106368","title":"Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction","year":2024,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Restless Legs Syndrome Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; European Regional Development Fund; Science and Technology Facilities Council; University of Thessaly; Engineering and Physical Sciences Research Council; Department of Health and Social Care; Medical Research Council; Canadian Institutes of Health Research; NIHR BioResource; Scottish Government; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Dell EMC; Deutsche Forschungsgemeinschaft; Health and Social Care Research and Development Division; Public Health Agency; Economic and Social Research Council; European Commission; National Institute on Aging; NHS Blood and Transplant; National Institute for Health and Care Research; Emory University; National Institute of Neurological Disorders and Stroke; British Heart Foundation; National Institutes of Health; Wellcome Trust; Univerzita Karlova v Praze; Restless Legs Syndrome Foundation; Heart and Stroke Foundation of Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"Nucleofection; Hyporeflexia; TSG101; Gestational period; Demotion; Dysgeusia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0105729,0.002534733,0.004380209,0.003769958,0.0004725124,0.002366778,0.0009131143,0.001096014,0.002219975],"category_scores_gemma":[0.01650227,0.0006958194,0.01819934,0.004439477,0.0003375915,0.0008306709,0.001157973,0.001581348,0.0002717087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006009243,"about_ca_system_score_gemma":0.0008006014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00457416,"about_ca_topic_score_gemma":0.007710981,"domain_scores_codex":[0.9930502,0.004131406,0.0006661125,0.001387381,0.0004799066,0.0002850007],"domain_scores_gemma":[0.9866722,0.009747664,0.0009904435,0.001884038,0.0004806218,0.0002250624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00453896,0.00004939281,0.2444386,0.005683356,0.697968,0.0004557942,0.00008953712,0.003850037,0.002772099,0.0006549211,0.002379615,0.03711967],"study_design_scores_gemma":[0.0007165367,0.0005704816,0.2596223,0.00106475,0.7178884,0.0005067527,0.0001273582,0.007847837,0.001482127,0.00397636,0.006134164,0.00006293898],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3648794,0.5883773,0.02850866,0.003313857,0.001040098,0.0001435356,0.01015806,0.0007537134,0.002825505],"genre_scores_gemma":[0.9567988,0.03214854,0.006475388,0.0005674856,0.0003630717,0.00009041733,0.002884231,0.0001183256,0.0005537193],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0105729,"threshold_uncertainty_score":0.05591547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05519742332538494,"score_gpt":0.3057485411295503,"score_spread":0.2505511178041654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}