{"id":"W6906715140","doi":"10.17863/cam.73083","title":"Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants","year":2019,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jonsson Comprehensive Cancer Center; National Center for Advancing Translational Sciences; Medical Research Council; National Institutes of Health; Kerry Group Kuok Foundation; Freistaat Sachsen; Centro de Investigación Biomédica en Red de Cáncer; National Cancer Institute; Liga Portuguesa Contra o Cancro; Pomorski Uniwersytet Medyczny W Szczecinie; Fox Chase Cancer Center; Ministero dello Sviluppo Economico; Institut National Du Cancer; Deutsche Krebshilfe; European Regional Development Fund; Centre National de la Recherche Scientifique; Ministerio de Economía y Competitividad; Landspítali Háskólasjúkrahús; Hungarian Scientific Research Fund; Korea Health Industry Development Institute; Generalitat de Catalunya; University of Toronto; Universitair Ziekenhuis Gent; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Russian Foundation for Basic Research; Universität Wien; Cancer Australia; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; National Institute for Health and Care Research; Memorial Sloan-Kettering Cancer Center; NRG Oncology; European Commission; NorthShore University HealthSystem; University of California, San Francisco; Universiteit Gent; Institut Català de la Salut; University of Pennsylvania; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Breast Cancer Research Foundation; McGill University; Univerzita Karlova v Praze; Clalit Health Services; Deutsches Krebsforschungszentrum; Odense Universitetshospital; Faculty of Medicine, McGill University; Peter MacCallum Cancer Centre; Helsingin ja Uudenmaan Sairaanhoitopiiri; American Cancer Society; Fonds Wetenschappelijk Onderzoek; National Council for Scientific Research; Cancer Center, University of Kansas; Cancerfonden; Istituto Oncologico Veneto; Royal Marsden NHS Foundation Trust; Canadian Institutes of Health Research; Dana-Farber Cancer Institute; European Social Fund; University of Chicago; Ministério da Ciência, Tecnologia e Inovação; Dr. Ralph and Marian Falk Medical Research Trust; Kansas Bioscience Authority; Cancer Research UK; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Centre Hospitalier Universitaire de Québec; Georgetown University; Susan G. Komen for the Cure; University of Pretoria; Instituto de Salud Carlos III; Ohio State University; National Health and Medical Research Council; Jewish General Hospital; Fisher Center for Alzheimer's Research Foundation","keywords":"Polygenic risk score; Ovarian cancer; Prospective cohort study; Breast cancer; Epithelial ovarian cancer; Cohort; Serous fluid; Population; Cohort study","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009846597,0.0003654403,0.0001950747,0.0006888384,0.0002237082,0.0004139056,0.0002604374,0.0004238629,0.00216581],"category_scores_gemma":[0.003607439,0.000197378,0.0005592531,0.0007089759,0.0002667277,0.0001961869,0.0003517931,0.0004497105,0.0001924745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001333806,"about_ca_system_score_gemma":0.0001537206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00266283,"about_ca_topic_score_gemma":0.001840615,"domain_scores_codex":[0.9995084,0.0001815639,0.00004107368,0.0001428888,0.00007214913,0.00005379933],"domain_scores_gemma":[0.9976484,0.0006973683,0.001033884,0.0002920964,0.0001334638,0.0001948744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001462203,0.00001595731,0.9979762,0.000004592034,0.0001769411,0.00004185804,0.00001761321,0.0000889989,0.0003791891,0.00002145137,0.0000420535,0.001088905],"study_design_scores_gemma":[0.00000633977,0.00006317924,0.9989648,0.00000233712,0.00006154413,0.0002356763,0.00001580395,0.0004377553,0.00009631745,0.00004066372,0.00007321801,0.000002266889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991187,0.0001674836,0.0002549004,0.00002271805,0.000002724132,0.000003102736,0.0002952202,0.000003939331,0.0001311474],"genre_scores_gemma":[0.999441,0.00004196616,0.0001464717,0.000006749716,0.000004923141,0.000002690521,0.0002642806,0.000001402943,0.00009050704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266283,"threshold_uncertainty_score":0.007245421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008243729409467862,"score_gpt":0.2285474422185885,"score_spread":0.2203037128091206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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