{"id":"W6906889304","doi":"10.17863/cam.79172","title":"Comprehensive epithelial tubo-ovarian cancer risk prediction model incorporating genetic and epidemiological risk factors","year":2021,"lang":"en","type":"article","venue":"Apollo","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 Health; National Institute for Health and Care Research; Cancer Research UK; Government of Canada","keywords":"Epidemiology; Risk assessment; Relative risk; Population; Polygenic risk score; Absolute risk reduction; Genetic epidemiology; Lifetime risk","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137215,0.000192183,0.0002101719,0.00002749967,0.0002277093,0.00002524194,0.00009689212,0.0002285644,0.00002954004],"category_scores_gemma":[0.0003255418,0.0001738548,0.0000851099,0.0001054386,0.0001445598,0.000005336659,0.0001519715,0.000204637,0.000003184983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005619836,"about_ca_system_score_gemma":0.0002404323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004052822,"about_ca_topic_score_gemma":0.0001672625,"domain_scores_codex":[0.9985819,0.0002504297,0.0002982634,0.0005332296,0.0001108642,0.0002253508],"domain_scores_gemma":[0.9991723,0.00006593887,0.000198997,0.000311445,0.0001511212,0.0001001764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006717874,0.00005957723,0.5164398,0.00002471316,0.0003256265,0.000008041354,0.0003202116,0.1478754,0.3196044,0.0001183959,0.001852365,0.01330431],"study_design_scores_gemma":[0.002005081,0.0003267529,0.6554306,0.00003539222,0.0003617097,0.00005465885,0.0007189768,0.1428059,0.183346,0.006861192,0.007288159,0.0007655785],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747267,0.002494601,0.02114153,0.0001588912,0.0003176965,0.0001477571,0.0008427831,0.00002281635,0.0001471963],"genre_scores_gemma":[0.9808832,0.002500747,0.01559484,0.0002570879,0.0003819458,0.0000512861,0.0001716406,0.00002478393,0.0001344846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1389908,"threshold_uncertainty_score":0.7089595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481499937340087,"score_gpt":0.2836709348516807,"score_spread":0.2588559354782798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}