{"id":"W6907700092","doi":"10.25345/c57r89","title":"MassIVE MSV000088105 - Fatty Acid Synthase inhibitor TVB-3166 prevents S-palmitoylation of coronavirus Spike proteins and limits infection","year":2021,"lang":"en","type":"dataset","venue":"UC San Diego","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Coronavirus; Severe acute respiratory syndrome coronavirus; Spike (software development); Enzyme; Spike Protein; Fatty acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004656341,0.000799307,0.0009350299,0.0005964165,0.0002371612,0.000144689,0.000308472,0.0007310171,0.001044786],"category_scores_gemma":[0.0009400842,0.0008635773,0.0002443656,0.0007809536,0.0002981831,0.0006166782,0.0003693477,0.0007556923,0.0007107333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004077295,"about_ca_system_score_gemma":0.0003166282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007703447,"about_ca_topic_score_gemma":0.002327904,"domain_scores_codex":[0.9956921,0.0005573009,0.001008145,0.001136948,0.0009818353,0.0006236666],"domain_scores_gemma":[0.9967307,0.0001441174,0.001248407,0.001208122,0.0003479054,0.0003207883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005483046,0.001411038,0.0082817,0.001367006,0.0004519017,0.000234387,0.0001330409,0.00003692731,0.08599976,0.00002028953,0.8955306,0.005985017],"study_design_scores_gemma":[0.004331497,0.001273575,0.07544831,0.002804396,0.001293073,0.0001695607,0.0001216521,0.00007601117,0.3063261,0.0001592539,0.605741,0.002255558],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.1846924,0.0009223733,0.00006756675,0.00001104842,0.0007488746,0.001955033,0.8113762,0.0001284923,0.00009801763],"genre_scores_gemma":[0.1419458,0.0002480279,0.0004470948,0.00003438723,0.0005808223,0.0003467671,0.8561805,0.0001639796,0.00005265366],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.2897896,"threshold_uncertainty_score":0.9998684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03005800410962518,"score_gpt":0.2940521060773421,"score_spread":0.2639941019677169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}