{"id":"W6907753799","doi":"10.25345/c5912d","title":"MassIVE MSV000084981 - RNF168 deficiency exacerbates R-loops and causes synthetic lethality in BRCA1/2-deficient tumors","year":2020,"lang":"en","type":"dataset","venue":"UC San Diego","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Lethality; Synthetic lethality; Cancer; Disease; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.001168151,0.001627154,0.002010332,0.001033273,0.0003552524,0.0003921898,0.001529128,0.0007716766,0.002136402],"category_scores_gemma":[0.002572323,0.001599787,0.0003087005,0.001712745,0.001211333,0.000288856,0.001353456,0.00199903,0.009818031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007683806,"about_ca_system_score_gemma":0.0005894271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003427016,"about_ca_topic_score_gemma":0.00511837,"domain_scores_codex":[0.9913432,0.0009771443,0.001598669,0.002758601,0.001568032,0.001754341],"domain_scores_gemma":[0.9950982,0.0009159886,0.001013506,0.002105209,0.0001862152,0.0006809042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001288456,0.0005944925,0.001201477,0.0009587802,0.00007502164,0.001491785,0.0004785767,0.0001110803,0.0003860501,0.0001134761,0.9943257,0.0001347259],"study_design_scores_gemma":[0.001674826,0.0004900178,0.0096774,0.001591897,0.0006517096,0.000264124,0.001642884,0.0001131091,0.0009605954,0.0005251219,0.9793422,0.003066148],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.04332903,0.004664877,0.000002416192,0.0001736803,0.0004953397,0.001402077,0.9491264,0.0003180481,0.0004881101],"genre_scores_gemma":[0.08269272,0.0004445078,0.0000872642,0.0004277685,0.0002129483,0.0002723972,0.9154339,0.0003443041,0.0000842324],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.03936369,"threshold_uncertainty_score":0.9996476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02351203954868192,"score_gpt":0.2666928917590859,"score_spread":0.243180852210404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}