{"id":"W6908615245","doi":"10.3389/fneur.2023.1284444/full","title":"Long-term safety, tolerability, and efficacy of efgartigimod (ADAPT+): interim results from a phase 3 open-label extension study in participants with generalized myasthenia gravis","year":2024,"lang":"en","type":"article","venue":"Leiden Repository (Leiden University)","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Argenx","keywords":"Myasthenia gravis; Adverse effect; Incidence (geometry); Interim; Clinical endpoint; Interim analysis; Neuromuscular disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004961272,0.0003761318,0.0009699255,0.0005099154,0.0001640182,0.0001713137,0.0004509572,0.0001415452,0.0000306841],"category_scores_gemma":[0.00008689033,0.0003212813,0.00008917472,0.0007608088,0.0002304539,0.0004465375,0.0005974539,0.0003647805,0.000008042991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096554,"about_ca_system_score_gemma":0.000266273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004073817,"about_ca_topic_score_gemma":0.001517579,"domain_scores_codex":[0.9967707,0.0004003655,0.0008349835,0.001106977,0.0004677175,0.0004192353],"domain_scores_gemma":[0.9980517,0.0002490948,0.0002384765,0.0009294654,0.0001953327,0.000335952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07135514,0.01171063,0.7841512,0.0003578437,0.001317706,0.03187115,0.009035719,0.00004369688,0.07950456,0.0004105735,0.0001661468,0.01007562],"study_design_scores_gemma":[0.06312589,0.00662664,0.915023,0.002913033,0.001303408,0.0002860932,0.001092605,0.001270295,0.007213898,0.00007790817,0.0004541058,0.0006131104],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963644,0.0003858775,0.0001332296,0.0003125686,0.0001843605,0.00181477,0.00005263638,0.00009609891,0.0006560617],"genre_scores_gemma":[0.9969018,0.00002751952,0.0004498235,0.00002860918,0.0000820163,0.000006158177,0.00005158989,0.00004682604,0.002405679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1308718,"threshold_uncertainty_score":0.9999239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06080074947281706,"score_gpt":0.3296286303355453,"score_spread":0.2688278808627283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}