{"id":"W6910296362","doi":"10.48350/197919","title":"A local drug delivery system prolongs graft survival by dampening T cell infiltration and neutrophil extracellular trap formation in vascularized composite allografts.","year":2024,"lang":"en","type":"article","venue":"Bern Open Repository and Information System (University of Bern)","topic":"Organ and Tissue Transplantation Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hand and Upper Limb Clinic","funders":"","keywords":"Neutrophil extracellular traps; Infiltration (HVAC); Immunosuppression; Tacrolimus; Complement system; Toxicity; Immune system; Drug delivery; Allotransplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005811988,0.000140122,0.0003332147,0.0002794128,0.0002308378,0.0002231118,0.0001287167,0.0001205547,0.000007419318],"category_scores_gemma":[0.000001077076,0.0001504103,0.00006008437,0.0002449388,0.00009321419,0.003264762,0.00006437393,0.0001907823,0.00001485032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001328818,"about_ca_system_score_gemma":0.00007272506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001563097,"about_ca_topic_score_gemma":0.00004328851,"domain_scores_codex":[0.9987249,0.0001529601,0.0004145731,0.0001856893,0.0003575342,0.0001643106],"domain_scores_gemma":[0.9993857,0.00005067704,0.0001622626,0.0001424557,0.000127033,0.000131904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01571256,0.0007663232,0.08526918,0.1405739,0.001786156,0.003435518,0.204422,0.000827939,0.4930848,0.02046289,0.002309582,0.03134923],"study_design_scores_gemma":[0.04110327,0.001653141,0.1313096,0.01444437,0.001945265,0.005894384,0.2667716,0.4351442,0.07943872,0.00001384371,0.02019426,0.002087355],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830399,0.0006644183,0.01044967,0.0001440783,0.00009835909,0.001093938,0.00003800687,0.00008077529,0.00439088],"genre_scores_gemma":[0.9987512,0.00009900537,0.0003201404,0.000009293043,0.00001145365,0.000003568715,0.0002496717,0.000008440655,0.0005472337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4343163,"threshold_uncertainty_score":0.6133556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008711566842693466,"score_gpt":0.2051684462722499,"score_spread":0.1964568794295565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}