{"id":"W6911482991","doi":"10.5281/zenodo.10957463","title":"Data from: Self-amplifying RNA generated with the modified nucleotides 5-methylcytidine and 5-methyluridine mediate strong expression and immunogenicity in vivo","year":2024,"lang":"en","type":"other","venue":"Open MIND","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"RNA; Nucleotide; Immunogenicity; Gene expression; Messenger RNA; Guanosine; Gene; Intron; Immune system; Uridine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008229684,0.0009819092,0.0005700505,0.001486249,0.001093622,0.001947415,0.001050199,0.001378856,0.4984477],"category_scores_gemma":[0.001360227,0.0003880894,0.0005235883,0.001445848,0.0008360505,0.0009860477,0.0009201484,0.001559077,0.2718119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007016534,"about_ca_system_score_gemma":0.001332219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002016189,"about_ca_topic_score_gemma":0.003623763,"domain_scores_codex":[0.999352,0.00004854245,0.00006744576,0.0001213807,0.0003362086,0.00007437509],"domain_scores_gemma":[0.9991634,0.0001464483,0.00008059148,0.0001503909,0.0002787443,0.0001803848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003665244,0.001208088,0.002640168,0.003632727,0.0001238874,0.0008129787,0.0003476753,0.0005307628,0.1084268,0.008100096,0.6082264,0.2622852],"study_design_scores_gemma":[0.0001751007,0.0002395391,0.004805279,0.0001478161,0.00002947589,0.0002860133,0.00006401959,0.0001606745,0.02628984,0.0006970132,0.967083,0.00002216842],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"dataset","genre_scores_codex":[0.01341835,0.003273721,0.00742487,0.003005571,0.003168116,0.0006938695,0.1579709,0.00359845,0.8074461],"genre_scores_gemma":[0.04897975,0.005216978,0.01088799,0.001250338,0.0004047905,0.0007749108,0.1572293,0.001359341,0.7738966],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.4984477,"threshold_uncertainty_score":0.7154036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07166381254506193,"score_gpt":0.3226910535975378,"score_spread":0.2510272410524759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}