{"id":"W6920139598","doi":"10.60692/0n3wp-c2q08","title":"A Survey of the Criteria Used for the Selection of Alternative Comparator Products by Participating Regulators and Organizations of the International Pharmaceutical Regulators Programme","year":2022,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Pharmaceutical Economics and Policy","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Innovator; Product (mathematics); Comparator; Bioequivalence; Selection (genetic algorithm); Interchangeability","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1637277,0.0005481612,0.000943173,0.007350421,0.002458547,0.006027042,0.002101849,0.003444985,0.003996042],"category_scores_gemma":[0.1909584,0.0008113691,0.001383219,0.008894727,0.002316978,0.004379882,0.00418937,0.003579309,0.001477218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003812639,"about_ca_system_score_gemma":0.01132486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003852222,"about_ca_topic_score_gemma":0.002074315,"domain_scores_codex":[0.8447683,0.07810024,0.02383762,0.005497955,0.04245226,0.005343697],"domain_scores_gemma":[0.6877645,0.1412784,0.06136886,0.01049668,0.09104542,0.008046092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001104033,0.001030507,0.3164834,0.007949824,0.0004159701,0.0009185141,0.06611349,0.001160724,0.01129186,0.01679171,0.08349641,0.4932437],"study_design_scores_gemma":[0.0001390262,0.001438357,0.3257296,0.009579433,0.0002140206,0.0018028,0.06197565,0.002134886,0.004310742,0.002641141,0.5896635,0.0003708479],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7300352,0.03536724,0.04343265,0.06423125,0.00125861,0.01087999,0.008530337,0.001086162,0.1051786],"genre_scores_gemma":[0.9078512,0.01845505,0.03771688,0.01740984,0.0003978478,0.005405765,0.005205664,0.0003728669,0.00718495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1637277,"threshold_uncertainty_score":0.8658854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1277978434662795,"score_gpt":0.2990204171875782,"score_spread":0.1712225737212987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}