{"id":"W6920457922","doi":"10.60692/y0b4j-5mz07","title":"Full population results from the core phase of CompLEEment-1, a phase 3b study of ribociclib plus letrozole as first-line therapy for advanced breast cancer in an expanded population","year":2021,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Letrozole; Adverse effect; Metastatic breast cancer; Neutropenia; Population; Breast cancer; Hazard ratio; Quality of life (healthcare)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003949344,0.0009751056,0.0009714127,0.0004440465,0.0007790798,0.0009763848,0.0008112866,0.0009446573,0.02532586],"category_scores_gemma":[0.002938398,0.0004229554,0.0008432058,0.0005410508,0.0003621137,0.0004888449,0.0006887925,0.001166074,0.004497887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005394657,"about_ca_system_score_gemma":0.001539634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001758161,"about_ca_topic_score_gemma":0.003707878,"domain_scores_codex":[0.9988797,0.0006585096,0.00005613979,0.0001222796,0.0001572149,0.0001261782],"domain_scores_gemma":[0.9987924,0.0002865658,0.000146466,0.0001881265,0.0001995297,0.0003868655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5329205,0.01615915,0.0372913,0.001923464,0.002332379,0.001241943,0.0005247046,0.002031511,0.03505266,0.0009726004,0.1454116,0.2241382],"study_design_scores_gemma":[0.395219,0.1657635,0.2466504,0.0003115888,0.002950585,0.002017577,0.000231498,0.001287078,0.007898774,0.001132514,0.1764299,0.0001075304],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.734858,0.006008312,0.006735413,0.002048041,0.0003035789,0.04138677,0.1548924,0.001078518,0.05268896],"genre_scores_gemma":[0.7276965,0.002693856,0.009139308,0.004019104,0.0005806683,0.03044685,0.200079,0.0003112606,0.0250334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02532586,"threshold_uncertainty_score":0.08472347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08972826809251612,"score_gpt":0.3588097447250519,"score_spread":0.2690814766325358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}