{"id":"W6920492811","doi":"10.60692/hr445-swk52","title":"Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium","year":2023,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University of Manitoba; CancerCare Manitoba; University Health Network; University of Toronto; SickKids Foundation; Université Laval; Hospital for Sick Children; Centre Hospitalier Universitaire Sainte-Justine; London Health Sciences Centre","funders":"","keywords":"Immunotherapy; Immune system; Nivolumab; Adverse effect; Immune checkpoint; Indel; Glioma; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005993693,0.0004170769,0.00055662,0.0001610656,0.0001151947,0.0003078704,0.0001991681,0.0001638772,0.0004209749],"category_scores_gemma":[0.0003764254,0.00006378168,0.0003508481,0.0001594971,0.0002345219,0.0001611535,0.000120171,0.0004356638,0.0001244703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002699611,"about_ca_system_score_gemma":0.0001914357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005187261,"about_ca_topic_score_gemma":0.0008832857,"domain_scores_codex":[0.9998575,0.00004816034,0.00001382003,0.00003125692,0.00001932203,0.00002987456],"domain_scores_gemma":[0.999827,0.00005200962,0.00003190504,0.00003321005,0.00001279783,0.00004317748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.06597868,0.005195664,0.09734249,0.0007098535,0.001998869,0.00125988,0.0006033199,0.00294795,0.2361945,0.0002632846,0.002791988,0.5847135],"study_design_scores_gemma":[0.009132303,0.2440804,0.6089841,0.00009682952,0.003332186,0.006692209,0.0002792212,0.003238465,0.1127115,0.0002517087,0.01113021,0.00007086051],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965243,0.002591137,0.0001989221,0.00006959693,0.000009646707,0.00001945817,0.00005981634,0.00001844489,0.000508636],"genre_scores_gemma":[0.9985037,0.0007916958,0.0002185659,0.0000588784,0.0000179932,0.00001393145,0.0002000496,0.000005632457,0.0001895803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005993693,"threshold_uncertainty_score":0.003169835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04754692661205817,"score_gpt":0.2808228717325144,"score_spread":0.2332759451204562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}