{"id":"W6920861180","doi":"10.6084/m9.figshare.19525315","title":"Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases","year":2022,"lang":"en","type":"article","venue":"Figshare","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Single-nucleotide polymorphism; Gene; Autophagy; Precision medicine; SNP; Expression quantitative trait loci; Genetic association; Phenotype; Human genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01127008,0.001026511,0.002524721,0.003248448,0.0006229943,0.002889981,0.001291741,0.002653997,0.003975276],"category_scores_gemma":[0.01639793,0.0003645475,0.001283322,0.002096238,0.003378274,0.003961196,0.002013529,0.005062263,0.001254226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00197981,"about_ca_system_score_gemma":0.001645369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002177691,"about_ca_topic_score_gemma":0.001879417,"domain_scores_codex":[0.996842,0.00168604,0.0002871903,0.0005152159,0.00054727,0.0001223222],"domain_scores_gemma":[0.9889803,0.007631343,0.0007934021,0.001007513,0.001119881,0.0004675063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007726154,0.00009051071,0.01209034,0.003005694,0.001671421,0.001076093,0.0006126799,0.002280851,0.003297563,0.08837857,0.1715063,0.7152174],"study_design_scores_gemma":[0.0002666877,0.0003262646,0.01921055,0.008207707,0.0009458804,0.001910323,0.0008498034,0.003262585,0.001462753,0.5396585,0.4236341,0.0002647738],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006580026,0.6538323,0.03826265,0.2815115,0.009455609,0.00003931508,0.001846049,0.0008790604,0.007593456],"genre_scores_gemma":[0.1312704,0.6220507,0.06848619,0.1300049,0.04021773,0.0001639682,0.001873936,0.0002511694,0.005681065],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01127008,"threshold_uncertainty_score":0.05960268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0783276671560212,"score_gpt":0.3507357339484897,"score_spread":0.2724080667924685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}