{"id":"W6920972336","doi":"10.6084/m9.figshare.25963049.v1","title":"Additional file 1 of Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Palbociclib; CRISPR; Biomarker; Triple-negative breast cancer; Breast cancer; In vivo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00003944344,0.0001656398,0.0003429438,0.000314488,0.00002582287,0.00001421887,0.000118266,0.00009074464,0.9809572],"category_scores_gemma":[0.0009591648,0.0001617904,0.0001017793,0.0008233755,0.00004665084,0.0003175819,0.00005348215,0.0001920772,0.0002155804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002830962,"about_ca_system_score_gemma":0.0004972239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000310485,"about_ca_topic_score_gemma":0.001840086,"domain_scores_codex":[0.9986855,0.00003755421,0.0003879669,0.0003239599,0.0003292388,0.0002357939],"domain_scores_gemma":[0.9983156,0.00103781,0.0001515398,0.0002032795,0.0002315579,0.0000601924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005694246,0.00006383017,0.00009595842,0.0007865838,0.00009200479,0.0000546569,0.0003011097,0.00002197366,0.0007450252,0.000006918382,0.9962383,0.001024232],"study_design_scores_gemma":[0.001108387,0.00003537067,0.2503939,0.02256536,0.00001718292,0.00002219539,0.0005173071,0.00007769631,0.004023161,0.0007521803,0.7202671,0.0002201538],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0005096422,0.001785188,9.597352e-7,0.0003384013,0.00003734884,0.0003525071,0.9928937,0.00003658907,0.004045664],"genre_scores_gemma":[0.09841068,0.00006134749,0.001019083,0.0004125579,0.0003054374,0.004443165,0.8589606,0.0001194434,0.03626774],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.9807416,"threshold_uncertainty_score":0.6597622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02310848007474992,"score_gpt":0.2967138263353508,"score_spread":0.2736053462606009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}