{"id":"W6921171988","doi":"10.6084/m9.figshare.28909345","title":"Additional file 1 of Prion replication in organotypic brain slice cultures is distinct from in vivo inoculation and is species dependent","year":2025,"lang":"en","type":"article","venue":"Figshare","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Replication (statistics); In vivo; Cell culture; Inoculation; Scrapie; Viral replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001951722,0.00127126,0.00156222,0.002771274,0.001330407,0.002245349,0.001930894,0.001612346,0.8924992],"category_scores_gemma":[0.0272471,0.001048346,0.001145111,0.00401342,0.0004335976,0.002197116,0.001145488,0.001419839,0.2578458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001030543,"about_ca_system_score_gemma":0.001739744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004427068,"about_ca_topic_score_gemma":0.007275141,"domain_scores_codex":[0.9992158,0.0001053612,0.0001388588,0.0002013273,0.000214835,0.0001236602],"domain_scores_gemma":[0.9702922,0.02345207,0.001239625,0.001668782,0.002632024,0.000715279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004935926,0.000123152,0.001555935,0.004387053,0.00006052461,0.0001493347,0.00008059054,0.0004620109,0.000720219,0.001064166,0.9822449,0.008658649],"study_design_scores_gemma":[0.005487585,0.0005239664,0.02644062,0.004994902,0.0002569127,0.001051261,0.0004448103,0.001955291,0.003794022,0.01808006,0.9366935,0.0002769987],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"other","genre_scores_codex":[0.0001680177,0.00002728111,0.000397251,0.00009392404,0.00004232988,0.00006561821,0.9977571,0.0005599344,0.0008885815],"genre_scores_gemma":[0.007345903,0.0002823352,0.004945993,0.0006372792,0.000134703,0.001645125,0.9741998,0.002022168,0.008786722],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.8924992,"threshold_uncertainty_score":0.1533368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106252480639619,"score_gpt":0.2532181638134747,"score_spread":0.2425929157495128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}