{"id":"W6921227559","doi":"10.6084/m9.figshare.c.7591683.v1","title":"Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib","year":2024,"lang":"en","type":"other","venue":"Figshare","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Olaparib; PALB2; Ovarian cancer; PARP inhibitor; Homologous recombination; Genome instability; Germline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004439376,0.0002344383,0.0009995974,0.0006770261,0.0003004103,0.0009521423,0.0003361537,0.000407014,0.000613338],"category_scores_gemma":[0.00675315,0.0002255094,0.0005796114,0.001191421,0.0004571534,0.0004313109,0.0004543978,0.0004804497,0.00009741108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007970249,"about_ca_system_score_gemma":0.0004838265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000406702,"about_ca_topic_score_gemma":0.0009166674,"domain_scores_codex":[0.9957808,0.002463784,0.0006548209,0.0005271963,0.0004195835,0.0001538127],"domain_scores_gemma":[0.9926201,0.003194477,0.002875331,0.0002918185,0.0004119208,0.0006064902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05810966,0.000383034,0.8895034,0.0004991816,0.003035327,0.0002685962,0.0003319632,0.0006381636,0.007815891,0.00008411822,0.0008229212,0.03850776],"study_design_scores_gemma":[0.009085166,0.01969711,0.9582229,0.0001071555,0.002593983,0.001628839,0.0002568595,0.001032153,0.003453127,0.0002173474,0.003670722,0.00003460653],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950452,0.003754684,0.0001427582,0.0001010545,0.000006639737,0.00009646735,0.0004519566,0.000008744399,0.0003924977],"genre_scores_gemma":[0.9985448,0.0003325338,0.0001513348,0.0000942365,0.00001207556,0.00009398565,0.0006883134,0.000002688534,0.00008005295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004439376,"threshold_uncertainty_score":0.02347791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2557243807452898,"score_gpt":0.4816372647154002,"score_spread":0.2259128839701104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}