{"id":"W6921267354","doi":"10.6084/m9.figshare.c.6985602","title":"Mimicking hypomethylation of FUS requires liquid–liquid phase separation to induce synaptic dysfunctions","year":2024,"lang":"en","type":"other","venue":"Figshare","topic":"Meromorphic and Entire Functions","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Postsynaptic potential; Synapse; Frontotemporal lobar degeneration; Excitatory postsynaptic potential; Dendritic spine; Degeneration (medical); Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001085244,0.0003210638,0.0004293479,0.0006150131,0.00006516866,0.00004544047,0.0001885988,0.000431514,0.2668767],"category_scores_gemma":[0.001734699,0.0003189483,0.0001718488,0.0005578999,0.00001090424,0.00008475267,0.0001130345,0.0002996869,0.008357929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008990877,"about_ca_system_score_gemma":0.0001212849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003553005,"about_ca_topic_score_gemma":0.00009435813,"domain_scores_codex":[0.9984096,0.00006651589,0.0004884929,0.0004354077,0.0003494391,0.0002505877],"domain_scores_gemma":[0.9986295,0.0002020929,0.0003537393,0.0005587333,0.0001333706,0.0001225591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004962305,0.0001090171,5.642717e-8,0.001262638,0.0002121531,0.000008594254,0.0002526803,0.00000768518,0.001229002,0.0005758682,0.9960498,0.0002428646],"study_design_scores_gemma":[0.000335953,0.000778062,6.980099e-7,0.01001555,0.0003097968,0.00001536492,0.00007914031,0.00009497703,0.0013634,0.000619043,0.9859434,0.0004445505],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.001171591,0.002448119,0.001634929,0.0003853481,0.002427181,0.002549527,0.2879767,0.001615774,0.6997908],"genre_scores_gemma":[0.01730901,0.00002377391,0.002439725,0.0001729489,0.002143291,0.001303507,0.1081885,0.001378134,0.8670412],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.2585187,"threshold_uncertainty_score":0.9999263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1512913335365013,"score_gpt":0.3898874844653013,"score_spread":0.2385961509288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}