{"id":"W6921274691","doi":"10.6084/m9.figshare.c.7165968.v1","title":"An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders","year":2024,"lang":"en","type":"other","venue":"Figshare","topic":"Libraries and Information Services","field":"Arts and Humanities","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Université de Montréal; McGill University","funders":"","keywords":"Microglia; Transcriptome; Inflammation; Stem cell; Purinergic receptor; Induced pluripotent stem cell; Neuroinflammation; Cell; Cell type","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00002104277,0.0001411648,0.0001521949,0.0001037451,0.00003825727,0.000199164,0.0002564047,0.00007535975,0.08598311],"category_scores_gemma":[0.000001708521,0.00009520149,0.00001939347,0.00005897829,0.000004233622,0.0001863073,0.00006187294,0.0001025063,0.00103186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000483201,"about_ca_system_score_gemma":0.00001291263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006028091,"about_ca_topic_score_gemma":0.006720188,"domain_scores_codex":[0.9993656,0.00003491842,0.000229851,0.0001682555,0.0001217025,0.00007968104],"domain_scores_gemma":[0.9995661,0.000020542,0.0001611082,0.0002002011,0.0000282322,0.00002386062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001413516,0.0001006738,0.000002774261,0.0006474085,0.00005121582,6.477484e-7,0.1200416,0.000002659117,0.000005458899,0.000412676,0.8756472,0.00307352],"study_design_scores_gemma":[0.0002375539,0.0001201337,0.00002268761,0.0006671181,0.000009869258,4.218503e-8,0.02545797,0.0001169255,0.0000289,0.00004243743,0.9731762,0.0001201477],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"protocol","genre_scores_codex":[0.001052025,0.0004199153,1.316788e-7,0.0001864579,0.0001052791,0.1562456,0.4142516,0.0002548198,0.4274842],"genre_scores_gemma":[0.08935831,0.000007861436,0.00001970228,0.00241687,0.001196295,0.5607645,0.1172914,0.0008651437,0.2280799],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.4045188,"threshold_uncertainty_score":0.999746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03243155963807915,"score_gpt":0.2475581431546168,"score_spread":0.2151265835165377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}