{"id":"W6921460485","doi":"10.64336/001c.29109","title":"The discovery of new acetylcholinesterase inhibitors as potential therapeutics for Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Journal of High School Science","topic":"Education Methods and Technologies","field":"Social Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surrey Memorial Hospital","funders":"","keywords":"Acetylcholinesterase; Disease; Acetylcholine; Neurotransmitter; Neurotransmission; Drug discovery; Human disease; Neurotransmitter systems","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004538658,0.0005744893,0.001027852,0.000668486,0.0002929796,0.001216928,0.0004749165,0.0005941098,0.00255316],"category_scores_gemma":[0.0004522855,0.0002681756,0.0008340572,0.0004642524,0.0002710735,0.0008489527,0.0005507394,0.001008405,0.0005698481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004118987,"about_ca_system_score_gemma":0.0006647786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006742557,"about_ca_topic_score_gemma":0.001709288,"domain_scores_codex":[0.9998404,0.00004194559,0.000008615623,0.00002371104,0.00006071559,0.00002468146],"domain_scores_gemma":[0.9998994,0.00003237775,0.00002264077,0.000005056002,0.00002017879,0.00002035099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001070544,0.002060162,0.007347661,0.007137212,0.0008595514,0.002870776,0.0003553412,0.07878742,0.2222122,0.06476065,0.01575263,0.5967859],"study_design_scores_gemma":[0.001892461,0.0103734,0.009113719,0.002277782,0.002530638,0.004163918,0.0006444547,0.2814922,0.1922962,0.04171615,0.4532019,0.0002971643],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4545074,0.3963116,0.09586285,0.006826705,0.001088484,0.0006710581,0.001267854,0.0008950351,0.04256902],"genre_scores_gemma":[0.6944628,0.2309906,0.06044288,0.001536397,0.0002520812,0.0003455818,0.001006872,0.00006165761,0.01090111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00255316,"threshold_uncertainty_score":0.008541167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05425821884695287,"score_gpt":0.4044072117536822,"score_spread":0.3501489929067294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}