{"id":"W6922053495","doi":"10.1186/s12874-024-02408-x.pdf","title":"The role of the estimand framework in the analysis of patient-reported outcomes in single-arm trials: a case study in oncology","year":2024,"lang":"en","type":"article","venue":"Leiden Repository (Leiden University)","topic":"Cancer survivorship and care","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Health Canada; European Society for Medical Oncology; European Commission; European Federation of Pharmaceutical Industries and Associations; American Society of Clinical Oncology","keywords":"Discontinuation; Clinical trial; Quality of life (healthcare); Outcome (game theory); Quality (philosophy); Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4214394,0.001711328,0.003596597,0.00281006,0.001492466,0.007199426,0.003571663,0.008769359,0.004000899],"category_scores_gemma":[0.5897052,0.001251168,0.006524632,0.003305579,0.01032404,0.007843686,0.005636663,0.01435986,0.0006775935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004441579,"about_ca_system_score_gemma":0.007891563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003821418,"about_ca_topic_score_gemma":0.003015177,"domain_scores_codex":[0.4472667,0.5303392,0.006974986,0.004935795,0.009174377,0.001308881],"domain_scores_gemma":[0.1266938,0.8464815,0.008246224,0.01368013,0.004178802,0.0007195105],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001451807,0.0003629881,0.01464251,0.002985854,0.001685517,0.00226668,0.002967296,0.05063326,0.0004770255,0.795777,0.00746538,0.1192847],"study_design_scores_gemma":[0.0006944062,0.001101069,0.002684181,0.003212181,0.0007052299,0.001477649,0.000847385,0.2083406,0.001438965,0.7528719,0.02639374,0.0002327747],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01081109,0.006903873,0.9460712,0.02660108,0.0004066834,0.0009712175,0.0002750558,0.0001787261,0.007781063],"genre_scores_gemma":[0.2379333,0.00322193,0.7444386,0.008296528,0.0009364474,0.003515632,0.0001844187,0.0002615601,0.001211481],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.5785606,"threshold_uncertainty_score":0.7134682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03044857867516584,"score_gpt":0.3106383226716926,"score_spread":0.2801897439965267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}