{"id":"W6922074915","doi":"10.1212/wnl.96.15_supplement.4350","title":"Novel Receptor Activity Mapping of Methysergide and its Metabolite, Methylergometrine, Provides a Mechanistic Rationale for both the Clinically Observed Efficacy and Risk of Fibrosis in Patients with Migraine (4350)","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Methysergide; Migraine; Fibrosis; Receptor; Migraine Disorders","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004160207,0.0002301286,0.0003255398,0.0002177887,0.0001465414,0.0003030523,0.0001886204,0.0004252933,0.002808716],"category_scores_gemma":[0.0004073061,0.0001091023,0.0002382331,0.0001426572,0.0002974022,0.0002442603,0.0001026109,0.0004356437,0.0003344485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001713198,"about_ca_system_score_gemma":0.0001214117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006711969,"about_ca_topic_score_gemma":0.001151896,"domain_scores_codex":[0.9998592,0.00007443463,0.000007762667,0.00002187611,0.00001492377,0.00002179666],"domain_scores_gemma":[0.9998195,0.00007027861,0.00004518002,0.00002134137,0.00001584887,0.0000279044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005651572,0.0004173571,0.02398628,0.0001220079,0.0001000593,0.0004443538,0.0001080195,0.0001651972,0.9495111,0.0004671562,0.000163761,0.01886309],"study_design_scores_gemma":[0.001463719,0.02826976,0.3694374,0.0000498018,0.000374156,0.006345756,0.0004284715,0.002697538,0.5842869,0.0007607506,0.00585178,0.0000338768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915506,0.002654367,0.003477769,0.0001400198,0.00002706553,0.00006059584,0.0001530726,0.00002220065,0.001914415],"genre_scores_gemma":[0.9968213,0.0004011565,0.00190213,0.00007058509,0.0000229856,0.0000352187,0.0001080343,0.000004173365,0.0006345051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002808716,"threshold_uncertainty_score":0.009396076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05002139420341917,"score_gpt":0.2868647941941352,"score_spread":0.2368433999907161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}