{"id":"W6922286346","doi":"10.11575/prism/33017","title":"IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype","year":2017,"lang":"en","type":"other","venue":"University of Calgary","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Alberta Innovates","keywords":"Chondrogenesis; Mesenchymal stem cell; Chondrocyte; Hyaline cartilage; Gene expression; Synovial membrane; Cartilage; Glycosaminoglycan; Synovial fluid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001145462,0.00037774,0.0006014534,0.0004386455,0.0003205029,0.00001582161,0.0009770893,0.0005021336,0.0008120464],"category_scores_gemma":[0.0000179419,0.000331187,0.0003916406,0.0001750723,0.0004274205,0.0001092573,0.0002066622,0.0003532355,0.00009420209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001544701,"about_ca_system_score_gemma":0.0001852536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002101605,"about_ca_topic_score_gemma":0.002145113,"domain_scores_codex":[0.9983281,0.0002049466,0.0001935199,0.0004732954,0.0005285661,0.0002715811],"domain_scores_gemma":[0.9984562,0.000007939482,0.0003054829,0.0009746632,0.0001507046,0.0001049914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006019889,0.0004767116,0.0008844322,0.0002726013,0.001066768,0.00001241772,0.001211976,0.00001890035,0.9796114,0.0003007964,0.01302757,0.002514448],"study_design_scores_gemma":[0.02763159,0.003288518,0.228461,0.006976986,0.01413235,0.0001739526,0.0009337988,0.001407116,0.4790703,0.00115946,0.2294192,0.007345653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652848,0.000211662,0.002115924,0.00005235698,0.0007005737,0.001503255,0.0004915333,0.0001814402,0.02945842],"genre_scores_gemma":[0.9214894,0.00003055838,0.0002631058,0.000008353297,0.0002706021,8.330865e-7,0.0002050836,0.0003723161,0.07735974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5005411,"threshold_uncertainty_score":0.999914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350978921581379,"score_gpt":0.1991244293704994,"score_spread":0.1856146401546856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}