{"id":"W6922369592","doi":"10.1021/jm400380m.s001","title":"The Discovery\\nof PLK4 Inhibitors: (<i>E</i>)‑3-((1<i>H</i>‑Indazol-6-yl)methylene)indolin-2-ones\\nas Novel Antiproliferative Agents","year":2016,"lang":"en","type":"article","venue":"Figshare","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Kinase; In vitro; Cell cycle checkpoint; Polo-like kinase; Cell cycle; Mitosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002910536,0.0005190104,0.0002877111,0.0004269913,0.0002365495,0.0007771697,0.0004615711,0.0003844918,0.00253339],"category_scores_gemma":[0.0001861778,0.0002806259,0.0003099963,0.000246503,0.0003048126,0.0005354574,0.000468339,0.0008933404,0.001024467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006350959,"about_ca_system_score_gemma":0.0007030944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005354553,"about_ca_topic_score_gemma":0.001600554,"domain_scores_codex":[0.9998779,0.00001878487,0.000007216462,0.00002590219,0.00004121315,0.00002888548],"domain_scores_gemma":[0.9999521,0.000005685984,0.00001100036,0.000005383233,0.00001154643,0.00001430027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001070887,0.0005668959,0.0009997722,0.001400763,0.00008691914,0.0007225421,0.000179992,0.009184633,0.8053103,0.01304417,0.00675852,0.1606747],"study_design_scores_gemma":[0.0005619485,0.002548348,0.002440286,0.000159655,0.00008331514,0.0008640569,0.00008827687,0.009021887,0.8549842,0.002000931,0.1271837,0.00006334172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8057717,0.07202012,0.04163193,0.00440345,0.0008870545,0.0008826511,0.003085377,0.00107851,0.07023919],"genre_scores_gemma":[0.8806956,0.05096445,0.01954612,0.001046662,0.000171631,0.0004100134,0.002010012,0.00008432998,0.04507117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00253339,"threshold_uncertainty_score":0.008475006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774102021500046,"score_gpt":0.248276385451893,"score_spread":0.2305353652368926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}