{"id":"W6923475661","doi":"10.14288/1.0449256","title":"Canadian Recommendations for Germline Genetic Testing of Patients with Breast Cancer : A Call to Action","year":2025,"lang":"en","type":"article","venue":"Open Collections","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic testing; Breast cancer; Genetic counseling; Germline; Call to action; Hereditary Cancer; Clinical trial; Health professionals; Government (linguistics)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04147078,0.001113386,0.001575657,0.0049714,0.008647913,0.006953844,0.008720596,0.01854746,0.01104818],"category_scores_gemma":[0.1159492,0.001187381,0.003809784,0.005127398,0.008030627,0.004908267,0.005813998,0.02382529,0.002996727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.06418514,"about_ca_system_score_gemma":0.3712467,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9330401,"about_ca_topic_score_gemma":0.9606148,"domain_scores_codex":[0.9587034,0.01042187,0.00460325,0.001725242,0.01962253,0.00492372],"domain_scores_gemma":[0.7469614,0.03737945,0.004936889,0.005116112,0.1723966,0.03320961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002902269,0.00006663587,0.0022908,0.0004065652,0.00003400423,0.0003202178,0.0009682106,0.0002324583,0.0002864756,0.004872227,0.9540054,0.03648796],"study_design_scores_gemma":[0.0001267564,0.0000406173,0.007862753,0.003203057,0.00010607,0.0004254236,0.002840097,0.0004585293,0.0002800438,0.006637036,0.9778047,0.000214903],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.000693563,0.006253671,0.001899327,0.9716263,0.00557268,0.0002863931,0.0007775975,0.0002228012,0.01266757],"genre_scores_gemma":[0.02241234,0.02160688,0.06514643,0.8570558,0.004114805,0.0007919695,0.002738575,0.0003134573,0.02581974],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.06695992,"threshold_uncertainty_score":0.4656979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942890892157844,"score_gpt":0.3115760103746369,"score_spread":0.2921471014530585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}