{"id":"W6925378919","doi":"10.17863/cam.50374","title":"Eleven grand challenges in single-cell data science.","year":2020,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Mechanics and Biomechanics Studies","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Human Genome Research Institute; Cancer Research UK Cambridge Institute, University of Cambridge; Helmholtz Zentrum München; BC Cancer Agency; National Health and Medical Research Council; Engineering and Physical Sciences Research Council; National Institutes of Health; Oncode Institute; BC Cancer Foundation; Terry Fox Research Institute; I.M. Sechenov First Moscow State Medical University; Alan Turing Institute; Swiss Institute of Bioinformatics; Universität Zürich; Klaus Tschira Stiftung; Cycle for Survival; Radboud Universitair Medisch Centrum; Universitair Medisch Centrum Groningen; Medical Research Council; Leids Universitair Medisch Centrum; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Eidgenössische Technische Hochschule Zürich; Bundesministerium für Bildung und Forschung; Universität des Saarlandes; Institute for Research in Biomedicine; Technische Universiteit Delft; Universiteit Utrecht; Rijksuniversiteit Groningen; Deutsche Krebshilfe; Universiteit Leiden; SystemsX.ch; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Cancer Society Research Institute; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Wageningen University and Research; Cancer Research UK; Radboud Universiteit; Barcelona Institute of Science and Technology; European Molecular Biology Laboratory; Deutsches Krebsforschungszentrum; Universiteit van Amsterdam; Georgia State University; Silicon Valley Community Foundation; Princeton University; Johns Hopkins University; Broad Institute; Universität Duisburg-Essen; University of Connecticut; National Science Foundation; Massachusetts General Hospital; Imperial College London","keywords":"Nucleofection; Gestational period; TSG101; Dysgeusia; Liquation; Diafiltration; Emperipolesis; Durvalumab; Fusible alloy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842823,0.00009176196,0.0001836988,0.0001170495,0.00007051732,0.000008597882,0.0006618584,0.00004015088,0.00001208621],"category_scores_gemma":[0.00001463655,0.0001117752,0.00002840831,0.0004109046,0.0000673949,0.0002674657,0.0003987527,0.00008588653,0.00001882004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003233324,"about_ca_system_score_gemma":0.00002653552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004757857,"about_ca_topic_score_gemma":0.00009927579,"domain_scores_codex":[0.9992551,0.000008722327,0.00008037692,0.0002569135,0.0001930896,0.0002057709],"domain_scores_gemma":[0.9995486,0.00001677944,0.00002865307,0.0002848186,0.00003178934,0.0000893448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001358361,0.0003595275,0.000260708,0.001248726,0.0001899307,0.000204243,0.009778535,0.0003341088,0.8503132,0.04260147,0.01673752,0.07783614],"study_design_scores_gemma":[0.009110857,0.001302958,0.004084775,0.0003484086,0.0002781387,0.00001858612,0.04136855,0.5949897,0.1023177,0.001015112,0.2424606,0.002704578],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9046877,0.008785698,0.01180016,0.006231755,0.0005853515,0.0004736395,0.0003156388,0.0003579121,0.06676216],"genre_scores_gemma":[0.996406,0.002714523,0.0007668648,0.0000205365,0.00002156252,5.748794e-8,0.000008186807,0.000008437883,0.00005378993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7479956,"threshold_uncertainty_score":0.4558062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08452081584672314,"score_gpt":0.1988280521064414,"score_spread":0.1143072362597183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}