{"id":"W6926582854","doi":"10.25418/crick.11842797.v1","title":"The evolutionary history of 2,658 cancers.","year":2020,"lang":"en","type":"article","venue":"Figshare","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of Mental Health; Medical Research Council; Wellcome Trust; Hutchison Whampoa Limited; Fonds Wetenschappelijk Onderzoek; Natural Sciences and Engineering Research Council of Canada; European Commission; Francis Crick Institute; National Institutes of Health; University of Cambridge; Cancer Research UK; Li Ka Shing Foundation","keywords":"Isochromosome; Chromothripsis; Genome instability; Genome; Cancer genome sequencing; Genomics; Somatic evolution in cancer; Carcinogenesis; Exome sequencing","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004340364,0.0002915446,0.0002912384,0.001260334,0.0006093424,0.0005730579,0.0002170135,0.0004495234,0.00304865],"category_scores_gemma":[0.001037383,0.0001640665,0.0003090771,0.002007168,0.0002269968,0.0004736897,0.0006463647,0.0004022823,0.001061225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000426724,"about_ca_system_score_gemma":0.0003412796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002252455,"about_ca_topic_score_gemma":0.004818886,"domain_scores_codex":[0.9997727,0.00003956204,0.00001234959,0.00008315197,0.00006066727,0.00003149562],"domain_scores_gemma":[0.9995566,0.0001195975,0.0001332652,0.00006844816,0.00006864643,0.00005353272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008187748,0.00005978938,0.5571507,0.0008323797,0.0005825031,0.001540199,0.00142765,0.002701892,0.1321408,0.007619414,0.006950585,0.2881753],"study_design_scores_gemma":[0.00001100906,0.0001963789,0.8566241,0.0001332417,0.0002356281,0.004166718,0.0006184456,0.001682128,0.01175778,0.004423632,0.1200999,0.00005097681],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.922213,0.02562351,0.01850225,0.001392273,0.0001612365,0.0000609771,0.01845406,0.0002533483,0.01333936],"genre_scores_gemma":[0.9370817,0.01555215,0.01520024,0.0006307347,0.0000653465,0.00006040365,0.02475879,0.0001008496,0.006549862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00304865,"threshold_uncertainty_score":0.01019877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04684204705990978,"score_gpt":0.2325830418313477,"score_spread":0.185740994771438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}