{"id":"W6927358270","doi":"10.3205/17dgrh156","title":"Efficacy and safety of baricitinib versus placebo and adalimumab in patients with moderately-to-severely active rheumatoid arthritis and inadequate response to methotrexate (MTX-IR): summary results from the 52-week phase 3 RA-BEAM study","year":2017,"lang":"en","type":"article","venue":"German Medical Science (German Research Foundation)","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Eli Lilly (Canada)","funders":"","keywords":"Rheumatoid arthritis; Methotrexate; Adalimumab; Placebo; Phases of clinical research; Clinical trial; Placebo response; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002284614,0.0008630168,0.002468394,0.0003815283,0.0003322199,0.0008155241,0.0004597461,0.001034296,0.002372643],"category_scores_gemma":[0.001692115,0.0002938605,0.001809634,0.0003970859,0.0004463898,0.0006200685,0.0002181815,0.001476598,0.0004786975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005257374,"about_ca_system_score_gemma":0.0005999251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005023523,"about_ca_topic_score_gemma":0.001505952,"domain_scores_codex":[0.99934,0.0003639054,0.00006736061,0.00008706692,0.00006245776,0.00007922493],"domain_scores_gemma":[0.9986909,0.00040457,0.0004479942,0.00006249861,0.000072768,0.0003213337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9228748,0.003880006,0.005366014,0.0008411003,0.002777167,0.0000923394,0.00008028052,0.0007877792,0.006540299,0.00005519983,0.001579176,0.05512593],"study_design_scores_gemma":[0.6318942,0.298083,0.05654645,0.0001767583,0.005862771,0.0004733796,0.00008388601,0.001425704,0.002772404,0.0001840454,0.002418649,0.00007882129],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746755,0.02133241,0.000247403,0.0004850462,0.0001356385,0.0003710458,0.001094806,0.00005531375,0.001602833],"genre_scores_gemma":[0.9934779,0.003232194,0.0004193181,0.0005536827,0.0002232822,0.0002618454,0.001205897,0.00001126758,0.0006145543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002468394,"threshold_uncertainty_score":0.01208234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05220183814746664,"score_gpt":0.3996419198142923,"score_spread":0.3474400816668257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}