{"id":"W6927563914","doi":"10.3205/23nrwgu18","title":"Proteomic profiling of muscle invasive bladder cancer treated with neoadjuvant chemotherapy reveals unique biologic clusters with clinical relevance","year":2023,"lang":"en","type":"article","venue":"German Medical Science (German Research Foundation)","topic":"Aquatic Ecosystems and Phytoplankton Dynamics","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Bladder cancer; Cystectomy; Chemotherapy; Clinical significance; Neoadjuvant therapy; Retrospective cohort study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007932338,0.0002145911,0.0003848176,0.0002058407,0.0005605565,0.0000830159,0.001028779,0.0001546918,0.001286577],"category_scores_gemma":[0.000893302,0.0001362122,0.00004976488,0.003083079,0.004522615,0.0005038302,0.0003265648,0.0006297692,0.000425816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003709506,"about_ca_system_score_gemma":0.0009141244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006696149,"about_ca_topic_score_gemma":0.001290236,"domain_scores_codex":[0.9944135,0.0004853056,0.0006551379,0.0008710933,0.002637623,0.0009373368],"domain_scores_gemma":[0.9976932,0.0006792964,0.0002999434,0.0005853328,0.000201993,0.0005402669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005670508,0.0004775396,0.8326156,0.0003473101,0.000131204,0.0003183866,0.002020708,0.001432373,0.03996139,0.002744106,0.002281115,0.1171032],"study_design_scores_gemma":[0.002568569,0.001796841,0.9123552,0.001226143,0.00002582859,0.00004857739,0.0003539096,0.06789915,0.008434101,0.001602522,0.002939223,0.0007498843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950202,0.00001081975,0.0004972388,0.001706986,0.00007253999,0.001428625,0.00001042809,0.00008165112,0.001171564],"genre_scores_gemma":[0.9968233,0.0006319259,0.001222986,0.0002837443,0.00009338449,0.000269702,0.00004002959,0.00002524362,0.0006096968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1163533,"threshold_uncertainty_score":0.9996264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05461962078402491,"score_gpt":0.3991661505565694,"score_spread":0.3445465297725445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}