{"id":"W6929301843","doi":"10.48448/fc47-d134","title":"2-B-174 - Amyloid beta oligomers sensitizes Panx1 activation by NMDAR via ER resident STIM proteins","year":2021,"lang":"en","type":"other","venue":"Underline Science Inc.","topic":"Meta-analysis and systematic reviews","field":"Decision Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pannexin; NMDA receptor; Hippocampal formation; Endoplasmic reticulum; Mutant; Excitatory postsynaptic potential; Intracellular; HEK 293 cells; Gene knockdown","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008930641,0.0003629316,0.0002195486,0.000133018,0.0001429875,0.0001946728,0.0001534576,0.0002375648,0.002596442],"category_scores_gemma":[0.00006532015,0.0001150779,0.0002204264,0.00010376,0.0001217735,0.0001958115,0.0001984584,0.000541409,0.0007352806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468251,"about_ca_system_score_gemma":0.0001712981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002710409,"about_ca_topic_score_gemma":0.0004751871,"domain_scores_codex":[0.9999141,0.00001044519,0.000009410855,0.00001750512,0.00002548826,0.00002311658],"domain_scores_gemma":[0.9999566,0.000003958288,0.00001245643,0.000005509288,0.000007701165,0.00001375763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001503747,0.00003628033,0.0001315687,0.00003285261,0.000006568004,0.00007092857,0.00001044027,0.00001282886,0.9987406,0.00003208186,0.00006812624,0.0007074171],"study_design_scores_gemma":[0.00005613677,0.0009278167,0.007758067,0.00001609584,0.00002950939,0.0006503498,0.00006109066,0.0004051607,0.9850085,0.000071709,0.00500957,0.000006025092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936969,0.002694503,0.0007963266,0.000193416,0.0000776491,0.00002828672,0.0001842975,0.00008179727,0.002246869],"genre_scores_gemma":[0.9884343,0.002807421,0.001529823,0.0002030115,0.00003890986,0.00007367285,0.0004943884,0.00002968655,0.006388935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002596442,"threshold_uncertainty_score":0.008685946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3967664119272374,"score_gpt":0.465223148057697,"score_spread":0.0684567361304596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}