{"id":"W6939348028","doi":"10.6084/m9.figshare.15179246.v1","title":"Additional file 1 of De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy","year":2021,"lang":"en","type":"article","venue":"Open MIND","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Boltzmann constant; Electrophysiology; Conductance; Function (biology); Area under curve; Encephalopathy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001130979,0.001109617,0.001572402,0.001767598,0.001005566,0.001133181,0.001986494,0.00124624,0.8596933],"category_scores_gemma":[0.02357286,0.0003907949,0.0006878558,0.003005669,0.0002784068,0.001452691,0.0008710502,0.0007754641,0.09181921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006616978,"about_ca_system_score_gemma":0.001272058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005735141,"about_ca_topic_score_gemma":0.006760594,"domain_scores_codex":[0.9994777,0.0000724402,0.000122632,0.0001552509,0.00008938537,0.00008265227],"domain_scores_gemma":[0.9897687,0.007288772,0.0008914886,0.0007756926,0.0008709827,0.0004042461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001158499,0.0003060301,0.01061557,0.003728667,0.0001216925,0.001313708,0.0001893337,0.0005590928,0.0003954327,0.001269833,0.9581116,0.0222305],"study_design_scores_gemma":[0.01247967,0.001285361,0.1195486,0.01006887,0.0005550456,0.01633418,0.001244555,0.004176047,0.002024248,0.02111864,0.8108105,0.0003543629],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.001102365,0.00004442948,0.0005392577,0.0001943408,0.00004837248,0.000222645,0.9960455,0.0001536237,0.001649386],"genre_scores_gemma":[0.03147706,0.0004215789,0.00501475,0.0009796101,0.0003167827,0.003224457,0.944824,0.0005479226,0.01319388],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.8596933,"threshold_uncertainty_score":0.2001304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02800040263008804,"score_gpt":0.2768225984951996,"score_spread":0.2488221958651115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}