{"id":"W6939767888","doi":"10.6084/m9.figshare.25744317","title":"Additional file 1 of Mechanism of action, potency and efficacy: considerations for cell therapies","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Potency; Mechanism (biology); Cell; Product (mathematics); Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007155851,0.0007753721,0.00121829,0.0021513,0.0008374809,0.002042235,0.001706824,0.001577215,0.9043437],"category_scores_gemma":[0.07768798,0.0006298435,0.001122006,0.003698157,0.0003417727,0.002381262,0.001185289,0.001426181,0.2219897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001894996,"about_ca_system_score_gemma":0.003473606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003623548,"about_ca_topic_score_gemma":0.006339219,"domain_scores_codex":[0.9974526,0.000759347,0.0005588785,0.0003003575,0.0006873598,0.0002414253],"domain_scores_gemma":[0.9064169,0.07368916,0.005519771,0.00325992,0.00955359,0.001560611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007228543,0.00009701558,0.0008510298,0.00287805,0.00003617099,0.00003682296,0.00002735811,0.0002775815,0.00005898952,0.001197007,0.9813111,0.01250587],"study_design_scores_gemma":[0.005802948,0.0005090366,0.008536323,0.004547412,0.0001974319,0.0003612851,0.0001766351,0.0008826471,0.000569292,0.01083689,0.9674999,0.00008029694],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0001829719,0.00008096543,0.0005305866,0.0005903014,0.00007243954,0.0004456993,0.9927675,0.0002454645,0.005084195],"genre_scores_gemma":[0.01883974,0.00115886,0.01076567,0.004903608,0.0006900639,0.009896849,0.9029479,0.001519532,0.04927775],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.9043437,"threshold_uncertainty_score":0.1364422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08471419520195171,"score_gpt":0.3286717834675676,"score_spread":0.2439575882656159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}