{"id":"W6939767996","doi":"10.6084/m9.figshare.29849070","title":"Additional file 1 of LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome","year":2025,"lang":"en","type":"article","venue":"Open MIND","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Lysosome; Kinase; LRRK2; Protein kinase A; Tyrosine kinase; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00109684,0.001069469,0.001486709,0.001768515,0.001057869,0.001920492,0.001988561,0.001537544,0.9177272],"category_scores_gemma":[0.01562186,0.0007468687,0.001042749,0.002642055,0.0002704113,0.001929032,0.001016744,0.001055067,0.2586286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001348168,"about_ca_system_score_gemma":0.001740008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007937175,"about_ca_topic_score_gemma":0.01157439,"domain_scores_codex":[0.9994127,0.00007753967,0.00008657884,0.0001587151,0.0001686255,0.00009595064],"domain_scores_gemma":[0.9905723,0.006650761,0.0005855022,0.0006178884,0.001229855,0.0003437519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006588697,0.0001999009,0.002160755,0.004155517,0.00006785044,0.0001525923,0.00006770739,0.0007139352,0.0006535978,0.001983881,0.9760509,0.01313459],"study_design_scores_gemma":[0.006580281,0.0005562279,0.03390208,0.004723818,0.000259008,0.001281979,0.0004518198,0.003431156,0.004139348,0.02343126,0.9209814,0.0002615769],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0002104115,0.00005442967,0.0003812101,0.0001145813,0.00005335746,0.00006285937,0.9972863,0.0002902834,0.001546505],"genre_scores_gemma":[0.009172169,0.0003713871,0.00436889,0.0008831272,0.0001349926,0.001086078,0.9701398,0.0009780148,0.01286553],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.9177272,"threshold_uncertainty_score":0.1173522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02074654259563153,"score_gpt":0.2824112582209392,"score_spread":0.2616647156253077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}