{"id":"W6940061002","doi":"10.6084/m9.figshare.c.7367194","title":"Pembrolizumab plus epacadostat in patients with recurrent/metastatic head and neck squamous cell carcinoma (KEYNOTE-669/ECHO-304): a phase 3, randomized, open-label study","year":2024,"lang":"en","type":"other","venue":"Figshare","topic":"Mycorrhizal Fungi and Plant Interactions","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Hôtel-Dieu de Québec","funders":"","keywords":"Pembrolizumab; Adverse effect; Head and neck squamous-cell carcinoma; Clinical endpoint; Regimen; Phases of clinical research; Head and neck cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002232572,0.001099358,0.001943054,0.0003686144,0.0004445378,0.0009197639,0.0007691881,0.001297603,0.004383935],"category_scores_gemma":[0.0009353221,0.0005468253,0.001890952,0.0003583056,0.0008455688,0.001111381,0.000272302,0.002683127,0.0008101371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008030828,"about_ca_system_score_gemma":0.001298483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000924808,"about_ca_topic_score_gemma":0.002862668,"domain_scores_codex":[0.999458,0.0002692549,0.0000359151,0.0000948787,0.00005239409,0.00008953965],"domain_scores_gemma":[0.9992585,0.0001717082,0.000162739,0.00005831391,0.00006008391,0.0002887311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9393155,0.0256982,0.001785434,0.0008865822,0.001214909,0.00008640036,0.00008026241,0.0004850154,0.007861615,0.00009089434,0.00112184,0.02137328],"study_design_scores_gemma":[0.8191167,0.1746914,0.003628681,0.00003238382,0.0006251814,0.00006197225,0.00002999638,0.0004303415,0.000656559,0.00009368129,0.000616233,0.0000167838],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910909,0.003269181,0.000281046,0.0003519487,0.0002300161,0.002614016,0.0006997086,0.00007383656,0.001389364],"genre_scores_gemma":[0.9929468,0.001570256,0.0007901101,0.000827007,0.0002456744,0.001792492,0.0006185219,0.00001111135,0.001198044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004383935,"threshold_uncertainty_score":0.01466566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03177334504912584,"score_gpt":0.2789471268770677,"score_spread":0.2471737818279418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}